Iron handling by the human kidney: glomerular filtration and tubular reabsorption both contribute to urinary iron excretion

• Published in: American journal of physiology. Renal physiology Vol. 316; no. 3; pp. F606 - F614
• Main Authors: van Raaij, Sanne E. G., Rennings, Alexander J., Biemond, Bart J., Schols, Saskia E. M., Wiegerinck, Erwin T. G., Roelofs, Hennie M. J., Hoorn, Ewout J., Walsh, Stephen B., Nijenhuis, Tom, Swinkels, Dorine W., van Swelm, Rachel P. L.
• Format: Journal Article
• Language: English
• Published: United States 01.03.2019
• Subjects: Adult; Female; Glomerular Filtration Rate - physiology; Humans; Iron - urine; Iron Overload - metabolism; Iron Overload - urine; Kidney - metabolism; Kidney - physiopathology; Kidney Tubules, Proximal - metabolism; Kidney Tubules, Proximal - physiopathology; Male; iron; filtration; reabsorption; injury; urine

In physiological conditions, circulating iron can be filtered by the glomerulus and is almost completely reabsorbed by the tubular epithelium to prevent urinary iron wasting. Increased urinary iron concentrations have been associated with renal injury. However, it is not clear whether increased urin...