Characteristics of autoantibodies targeting 14-3-3 proteins and their association with clinical features in newly diagnosed giant cell arteritis

• Published in: Rheumatology (Oxford, England) Vol. 56; no. 5; p. kew469
• Main Authors: Kistner, Anne, Bigler, Marc B., Glatz, Kathrin, Egli, Simon B., Baldin, Fabian S., Marquardsen, Florian A., Mehling, Matthias, Rentsch, Katharina M., Staub, Daniel, Aschwanden, Markus, Recher, Mike, Daikeler, Thomas, Berger, Christoph T.
• Format: Journal Article
• Language: English
• Published: England 01.05.2017
• Subjects: 14-3-3 Proteins - immunology; Adult; Aged; Aged, 80 and over; Aortitis - immunology; Autoantibodies - metabolism; Biomarkers - metabolism; Female; Giant Cell Arteritis - diagnosis; Giant Cell Arteritis - immunology; Humans; Immunoglobulin G - metabolism; Male; Middle Aged; Stroke - immunology; Takayasu Arteritis - immunology; Toxoplasma - immunology; Toxoplasmosis - immunology; Vascular Remodeling - immunology; Young Adult; 14-3-3 proteins; giant cell arteritis; aortic aneurysm; multiplex; toxoplasmosis; large-vessel vasculitis; Takayasu’s arteritis; protein pulldown; autoantibodies; stroke

Autoantibodies are useful biomarkers for diagnosing and monitoring treatment in some autoimmune diseases. Antibodies against isoforms of 14-3-3 protein have been proposed as biomarkers for the presence of aortic aneurysm in large-vessel vasculitis (LVV). Here, we aimed to evaluate the diagnostic rol...