Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

• Published in: The European respiratory journal Vol. 54; no. 4; p. 1802244
• Main Authors: Belchamber, Kylie B.R., Singh, Richa, Batista, Craig M., Whyte, Moira K., Dockrell, David H., Kilty, Iain, Robinson, Matthew J., Wedzicha, Jadwiga A., Barnes, Peter J., Donnelly, Louise E.
• Format: Journal Article
• Language: English
• Published: England 01.10.2019
• Subjects: Aged; Bacteria; Cell Survival; Female; Haemophilus influenzae; Humans; In Vitro Techniques; Macrophages - immunology; Macrophages - metabolism; Macrophages - pathology; Macrophages, Alveolar - immunology; Macrophages, Alveolar - metabolism; Macrophages, Alveolar - pathology; Male; Membrane Potential, Mitochondrial; Microscopy, Confocal; Middle Aged; Mitochondria - metabolism; Phagocytosis - immunology; Pulmonary Disease, Chronic Obstructive - immunology; Pulmonary Disease, Chronic Obstructive - metabolism; Reactive Oxygen Species - metabolism; Streptococcus pneumoniae

Increased reactive oxygen species (ROS) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). This study examined the effect of exogenous and endogenous oxidative stress on macrophage phagocytosis in patients with COPD. Monocyte-derived macrophages (MDMs) were...