A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 17; no. 32; pp. e2101368 - n/a
• Main Authors: Zhou, Le‐Le, Guan, Qun, Li, Wen‐Yan, Zhang, Zhiyong, Li, Yan‐An, Dong, Yu‐Bin
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.08.2021
• Subjects: Antioxidants; cancer; Cell death; chemodynamic therapy; Covalence; covalent organic frameworks; Damage accumulation; ferroptosis; Glutathione; Hydrogen peroxide; Lipids; nanoparticles; Nanotechnology; Peroxidase

Chemodynamic therapy (CDT), which induces cell death by decomposing high levels of H2O2 in tumor cells into highly toxic ·OH, is recognized as a promising antineoplastic approach. However, current CDT approaches are often restricted by the highly controlled and upregulated cellular antioxidant defen...