Human red blood cells release microvesicles with distinct sizes and protein composition that alter neutrophil phagocytosis

• Published in: Journal of extracellular biology Vol. 2; no. 11
• Main Authors: Oliveira, Getulio Pereira, Welsh, Joshua A., Pinckney, Brandy, Palu, Cintia C., Lu, Shulin, Zimmerman, Alan, Barbosa, Raquel Hora, Sahu, Parul, Noshin, Maeesha, Gummuluru, Suryaram, Tigges, John, Jones, Jennifer Clare, Ivanov, Alexander R., Ghiran, Ionita C.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.11.2023; John Wiley and Sons Inc; Wiley
• Subjects: Biosynthesis; Calcimycin; Calcium homeostasis; Calcium ionophores; Calcium transport; Cell interactions; Electron microscopy; Erythrocytes; extracellular vesicles; Flow cytometry; Homeostasis; Internalization; Ionomycin; Ionophores; Leukocytes (neutrophilic); Membrane fusion; Membrane vesicles; Microscopy; Neutrophils; Phagocytosis; Plasma; Protein composition; Protein transport; Proteins; Proteomics; RBCs; Software; Extracellular vesicles; neutrophils; RBCs; calcium ionophores

Extracellular vesicles (EVs) are membrane‐bound structures released by cells and tissues into biofluids, involved in cell‐cell communication. In humans, circulating red blood cells (RBCs), represent the most common cell‐type in the body, generating daily large numbers of microvesicles. In vitro, RBC...