Stereodivergent Construction of 1,4‐Nonadjacent Stereocenters via Hydroalkylation of Racemic Allylic Alcohols Enabled by Copper/Ruthenium Relay Catalysis

• Published in: Angewandte Chemie International Edition Vol. 61; no. 36; pp. e202206517 - n/a
• Main Authors: Chang, Xin, Cheng, Xiang, Liu, Xue‐Tao, Fu, Cong, Wang, Wei‐Yi, Wang, Chun‐Jiang
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 05.09.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alcohols; Asymmetric Catalysis; Asymmetry; Borrowing-Hydrogen Strategy; Catalysis; Catalysts; Chemistry; Chemistry, Multidisciplinary; Copper; Enantiomers; Esters; Permutations; Physical Sciences; Relay; Relay Catalysis; Ruthenium; Science & Technology; Stereodivergent; Stereogenic Centers; Stereoisomerism; Stereoisomers; Stereoselectivity; Stereodivergent; ASYMMETRIC TRANSFER HYDROGENATION; ENANTIOSELECTIVE FUNCTIONALIZATION; Borrowing-Hydrogen Strategy; BORROWING HYDROGEN; ALKYLATION; ALLYLATION; AZOMETHINE YLIDES; ALPHA-AMINO-ACIDS; Stereogenic Centers; METHODOLOGY COOPERATIVE CATALYSIS; Relay Catalysis; Asymmetric Catalysis; SYNERGISTIC CU/PD CATALYSIS; DUAL CATALYSIS

An unprecedented hydroalkylation of racemic allylic alcohols and racemic ketimine esters enabled by Cu/Ru relay catalysis has been developed via merging the ruthenium‐catalyzed asymmetric borrowing‐hydrogen reaction with a copper‐catalyzed asymmetric Michael addition in a one‐pot procedure. The curr...