Herpes Simplex Treated With Antimicrobial Photodynamic Therapy: Randomized Controlled Trial

• Published in: Journal of oral pathology & medicine Vol. 54; no. 7; pp. 547 - 555
• Main Authors: La Selva, Andreia, Bezerra, Daniella Teixeira, Zerbinati, Rodrigo Melim, Gonçalves, Marcela Leticia Leal, Navarro, Ricardo Scarparo, Bello‐Silva, Marina Stella, Ando‐Suguimoto, Ellen Sayuri, Aranha, Ana Cecília Corrêa, Braz‐Silva, Paulo Henrique, Ramalho, Karen Muller, Motta, Lara Jansiski, Fernandes, Kristianne Porta Santos, Bussadori, Sandra Kalil, Mesquita‐Ferrari, Raquel Agnelli, Frochot, Céline, Horliana, Anna Carolina Ratto Tempestini
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.08.2025
• Subjects: Acyclovir; Acyclovir - administration & dosage; Acyclovir - therapeutic use; Adult; Antiviral Agents - administration & dosage; Antiviral Agents - therapeutic use; cold sores; Female; Herpes simplex; Herpes Simplex - drug therapy; Herpes Simplex - virology; Herpes viruses; Herpesvirus 1, Human - drug effects; Humans; laser; Lesions; Male; methylene blue; Middle Aged; Pain; photobiomodulation; Photochemotherapy - methods; Photodynamic therapy; Photosensitizing Agents - therapeutic use; Quality of Life; Recurrence; Remission; Saliva; Saliva - virology; Treatment Outcome; Viral Load; Young Adult; photobiomodulation; methylene blue; laser; cold sores; photodynamic therapy; herpes simplex

ABSTRACT Objective To compare the efficacy of antimicrobial photodynamic therapy (aPDT) with topical acyclovir in terms of healing time for herpes simplex lesions, recurrence rates, HSV‐1 quantification in secretion and saliva, pain levels, temperature changes, and outcomes measured by the Oral Heal...