Complement‐Opsonized NIR‐IIb Emissive Immunotracers for Dynamically Monitoring Neutrophils in Inflammation‐Related Diseases
Real‐time monitoring of neutrophil dynamics is crucial for timely diagnosis and effective treatment of inflammation‐related diseases, which requires a reliable tracer for in vivo tracking of neutrophils. However, immunotracers for neutrophils are extremely limited because of the difficulty in labeli...
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Published in | Advanced materials (Weinheim) Vol. 34; no. 34; pp. e2203477 - n/a |
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Abstract | Real‐time monitoring of neutrophil dynamics is crucial for timely diagnosis and effective treatment of inflammation‐related diseases, which requires a reliable tracer for in vivo tracking of neutrophils. However, immunotracers for neutrophils are extremely limited because of the difficulty in labeling the cells. Inspired by the natural biological function of the complement system, a strategy of enhancing the complement C3 opsonization of lanthanide‐doped nanoparticles (LnNPs) by modulating their surface chemistry, thus developing a near infrared‐IIb emissive nanotracer for neutrophils, is reported herein. Four kinds of surface‐modified LnNPs are fabricated, among which phospholipids DOPG‐modified LnNPs (LnNPs@PG) with weak antifouling ability and hydroxyl groups adsorb more complement C3 proteins and form covalent linkages with C3b active fragments under inflammation conditions, inducing enhanced complement C3 opsonization. Therefore, LnNPs@PG with enhanced complement C3 opsonization are capable of efficiently labeling inflammation‐stimulated neutrophils in vivo through complement‐receptors‐mediated phagocytosis and achieve dynamic monitoring neutrophils during cutaneous wound healing and cerebral ischemia/reperfusion.
Complement C3 opsonized near‐infrared‐IIb emissive immunotracers are captured by inflammation‐stimulated neutrophils in circulatory blood through complement‐receptors‐mediated phagocytosis, enabling dynamically monitoring neutrophils during cutaneous wound healing and cerebral ischemia/reperfusion. The strategy of modulating surface chemistry of nanosized imaging agents to enhance complement C3 opsonization provides a new insight to develop immunotracers for in vivo labeling and tracking neutrophils. |
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AbstractList | Real‐time monitoring of neutrophil dynamics is crucial for timely diagnosis and effective treatment of inflammation‐related diseases, which requires a reliable tracer for in vivo tracking of neutrophils. However, immunotracers for neutrophils are extremely limited because of the difficulty in labeling the cells. Inspired by the natural biological function of the complement system, a strategy of enhancing the complement C3 opsonization of lanthanide‐doped nanoparticles (LnNPs) by modulating their surface chemistry, thus developing a near infrared‐IIb emissive nanotracer for neutrophils, is reported herein. Four kinds of surface‐modified LnNPs are fabricated, among which phospholipids DOPG‐modified LnNPs (LnNPs@PG) with weak antifouling ability and hydroxyl groups adsorb more complement C3 proteins and form covalent linkages with C3b active fragments under inflammation conditions, inducing enhanced complement C3 opsonization. Therefore, LnNPs@PG with enhanced complement C3 opsonization are capable of efficiently labeling inflammation‐stimulated neutrophils in vivo through complement‐receptors‐mediated phagocytosis and achieve dynamic monitoring neutrophils during cutaneous wound healing and cerebral ischemia/reperfusion. Real‐time monitoring of neutrophil dynamics is crucial for timely diagnosis and effective treatment of inflammation‐related diseases, which requires a reliable tracer for in vivo tracking of neutrophils. However, immunotracers for neutrophils are extremely limited because of the difficulty in labeling the cells. Inspired by the natural biological function of the complement system, a strategy of enhancing the complement C3 opsonization of lanthanide‐doped nanoparticles (LnNPs) by modulating their surface chemistry, thus developing a near infrared‐IIb emissive nanotracer for neutrophils, is reported herein. Four kinds of surface‐modified LnNPs are fabricated, among which phospholipids DOPG‐modified LnNPs (LnNPs@PG) with weak antifouling ability and hydroxyl groups adsorb more complement C3 proteins and form covalent linkages with C3b active fragments under inflammation conditions, inducing enhanced complement C3 opsonization. Therefore, LnNPs@PG with enhanced complement C3 opsonization are capable of efficiently labeling inflammation‐stimulated neutrophils in vivo through complement‐receptors‐mediated phagocytosis and achieve dynamic monitoring neutrophils during cutaneous wound healing and cerebral ischemia/reperfusion. Complement C3 opsonized near‐infrared‐IIb emissive immunotracers are captured by inflammation‐stimulated neutrophils in circulatory blood through complement‐receptors‐mediated phagocytosis, enabling dynamically monitoring neutrophils during cutaneous wound healing and cerebral ischemia/reperfusion. The strategy of modulating surface chemistry of nanosized imaging agents to enhance complement C3 opsonization provides a new insight to develop immunotracers for in vivo labeling and tracking neutrophils. Abstract Real‐time monitoring of neutrophil dynamics is crucial for timely diagnosis and effective treatment of inflammation‐related diseases, which requires a reliable tracer for in vivo tracking of neutrophils. However, immunotracers for neutrophils are extremely limited because of the difficulty in labeling the cells. Inspired by the natural biological function of the complement system, a strategy of enhancing the complement C3 opsonization of lanthanide‐doped nanoparticles (LnNPs) by modulating their surface chemistry, thus developing a near infrared‐IIb emissive nanotracer for neutrophils, is reported herein. Four kinds of surface‐modified LnNPs are fabricated, among which phospholipids DOPG‐modified LnNPs (LnNPs@PG) with weak antifouling ability and hydroxyl groups adsorb more complement C3 proteins and form covalent linkages with C3b active fragments under inflammation conditions, inducing enhanced complement C3 opsonization. Therefore, LnNPs@PG with enhanced complement C3 opsonization are capable of efficiently labeling inflammation‐stimulated neutrophils in vivo through complement‐receptors‐mediated phagocytosis and achieve dynamic monitoring neutrophils during cutaneous wound healing and cerebral ischemia/reperfusion. |
Author | Zhao, Yaoyao Liu, Zhihong Zhang, Meng Wang, Zijun Shao, Yunlong |
Author_xml | – sequence: 1 givenname: Meng surname: Zhang fullname: Zhang, Meng organization: Wuhan University – sequence: 2 givenname: Zijun surname: Wang fullname: Wang, Zijun organization: Wuhan University – sequence: 3 givenname: Yunlong surname: Shao fullname: Shao, Yunlong organization: Beijing University of Technology – sequence: 4 givenname: Yaoyao surname: Zhao fullname: Zhao, Yaoyao email: zhaoyaoyao@bjut.edu.cn organization: Beijing University of Technology – sequence: 5 givenname: Zhihong orcidid: 0000-0003-1500-9342 surname: Liu fullname: Liu, Zhihong email: zhhliu@whu.edu.cn organization: Wuhan University |
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SubjectTerms | Complement complement C3 opsonization Hydroxyl groups in vivo tracking Inflammation Labeling lanthanide‐doped nanoparticles Materials science Monitoring Nanoparticles Neutrophils NIR‐II fluorescence imaging Phospholipids Wound healing |
Title | Complement‐Opsonized NIR‐IIb Emissive Immunotracers for Dynamically Monitoring Neutrophils in Inflammation‐Related Diseases |
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