Enhancement of basophil chemotaxis in vitro by virus-induced interferon

• Published in: The Journal of clinical investigation Vol. 67; no. 2; pp. 547 - 552
• Main Authors: Lett-Brown, M A, Aelvoet, M, Hooks, J J, Georgiades, J A, Thueson, D O, Grant, J A
• Format: Journal Article
• Language: English
• Published: United States 01.02.1981
• Subjects: Animals; Basophils - immunology; Basophils - physiology; Chemotactic Factors - biosynthesis; Chemotaxis, Leukocyte; Complement C5 - immunology; Humans; In Vitro Techniques; Interferons - immunology; Lymphokines - immunology; Mice; Monocytes; Parainfluenza Virus 1, Human - immunology; Species Specificity

It is well established that viral infections may precipitate or worsen attacks of bronchial asthma. Furthermore, in symptomatic atopic subjects, the local accumulation of basophils and the production of a basophil chemotactic factor have been reported. We have investigated the effect of cell-free su...