Transition‐Metal‐Free C2‐Functionalization of Pyridines through Aryne Three‐Component Coupling
The direct C2‐functionalization of pyridines through a transition‐metal‐free protocol by using aryne multicomponent coupling is demonstrated. The reaction allowed a broad‐scope synthesis of C2‐substituted pyridine derivatives bearing the −CF3 group in good yields with α,α,α‐trifluoroacetophenones as...
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Published in | Chemistry : a European journal Vol. 27; no. 55; pp. 13864 - 13869 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
01.10.2021
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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