Transition‐Metal‐Free C2‐Functionalization of Pyridines through Aryne Three‐Component Coupling

• Published in: Chemistry : a European journal Vol. 27; no. 55; pp. 13864 - 13869
• Main Authors: Guin, Avishek, Bhattacharjee, Subrata, Biju, Akkattu T.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.10.2021; Wiley Subscription Services, Inc
• Subjects: arynes; Carbonyl compounds; Carbonyls; Chemistry; Chemistry, Multidisciplinary; Coupling; Esters; Ketones; multicomponent coupling; Physical Sciences; pyridine; Pyridines; Science & Technology; Smiles rearrangement; transition-metal-free reactions; Smiles rearrangement; BENZYNES; multicomponent coupling; ARYLATION; pyridine; TERMINAL ALKYNES; transition-metal-free reactions; N-OXIDES; arynes; H BOND ADDITION; HETEROCYCLES; EMPLOYING ARYNES; REGIOSELECTIVE SYNTHESIS; GENERATION; MULTICOMPONENT REACTION

The direct C2‐functionalization of pyridines through a transition‐metal‐free protocol by using aryne multicomponent coupling is demonstrated. The reaction allowed a broad‐scope synthesis of C2‐substituted pyridine derivatives bearing the −CF3 group in good yields with α,α,α‐trifluoroacetophenones as...