Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes

• Published in: Journal of hypertension Vol. 25; no. 3; p. 565
• Main Authors: van Rijn, Marie Josee E, Schut, Anna F C, Aulchenko, Yurii S, Deinum, Jaap, Sayed-Tabatabaei, Fakhredin A, Yazdanpanah, Mojgan, Isaacs, Aaron, Axenovich, Tatiana I, Zorkoltseva, Irina V, Zillikens, M Carola, Pols, Huib A P, Witteman, Jacqueline C M, Oostra, Ben A, van Duijn, Cornelia M
• Format: Journal Article
• Language: English
• Published: England 01.03.2007
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensinogen - genetics; Blood Pressure - genetics; Cohort Studies; Female; Genetic Testing; Heterotrimeric GTP-Binding Proteins - genetics; Humans; Hypertension - genetics; Inheritance Patterns; Male; Middle Aged; Multifactorial Inheritance - genetics; Netherlands - ethnology; Pedigree; Polymorphism, Single Nucleotide; Receptor, Angiotensin, Type 1 - genetics; Sterol Regulatory Element Binding Protein 1 - genetics; Netherlands

To study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes. All participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure,...