The effect of reducing repetition time TR on the measurement of liver R2 for the purpose of measuring liver iron concentration
The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin‐density‐projection‐assisted R2‐magnetic resonance imaging for the purpose of measuring liver iron concentration were evaluated. Repeated liver R2 measurements were made using both protocols on 60 subjects with...
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Published in | Magnetic resonance in medicine Vol. 65; no. 5; pp. 1346 - 1351 |
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Abstract | The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin‐density‐projection‐assisted R2‐magnetic resonance imaging for the purpose of measuring liver iron concentration were evaluated. Repeated liver R2 measurements were made using both protocols on 60 subjects with liver iron concentrations ranging from 0.5 to 48.6 mg Fe (g dry tissue)−1. The mean total scan time at repetition time 1000 ms was 42% of that at repetition time 2500 ms. The repeatability coefficients for the two protocols were not significantly different from each other. A systematic difference in the measured R2 using each protocol was found indicating that an adjustment factor is required when one protocol is used to replace the other. The 95% limits of agreement between the two protocols were not significantly different from their repeatability coefficients indicating that the protocols can be interchanged without any significant change in accuracy or precision of liver iron concentration measurement. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc. |
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AbstractList | The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin-density-projection-assisted R2-magnetic resonance imaging for the purpose of measuring liver iron concentration were evaluated. Repeated liver R2 measurements were made using both protocols on 60 subjects with liver iron concentrations ranging from 0.5 to 48.6 mg Fe (g dry tissue)(-1). The mean total scan time at repetition time 1000 ms was 42% of that at repetition time 2500 ms. The repeatability coefficients for the two protocols were not significantly different from each other. A systematic difference in the measured R2 using each protocol was found indicating that an adjustment factor is required when one protocol is used to replace the other. The 95% limits of agreement between the two protocols were not significantly different from their repeatability coefficients indicating that the protocols can be interchanged without any significant change in accuracy or precision of liver iron concentration measurement. The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin-density-projection-assisted R2-magnetic resonance imaging for the purpose of measuring liver iron concentration were evaluated. Repeated liver R2 measurements were made using both protocols on 60 subjects with liver iron concentrations ranging from 0.5 to 48.6 mg Fe (g dry tissue)-1. The mean total scan time at repetition time 1000 ms was 42% of that at repetition time 2500 ms. The repeatability coefficients for the two protocols were not significantly different from each other. A systematic difference in the measured R2 using each protocol was found indicating that an adjustment factor is required when one protocol is used to replace the other. The 95% limits of agreement between the two protocols were not significantly different from their repeatability coefficients indicating that the protocols can be interchanged without any significant change in accuracy or precision of liver iron concentration measurement. Magn Reson Med, 2011. © 2010 Wiley-Liss, Inc. The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin-density-projection-assisted R2-magnetic resonance imaging for the purpose of measuring liver iron concentration were evaluated. Repeated liver R2 measurements were made using both protocols on 60 subjects with liver iron concentrations ranging from 0.5 to 48.6 mg Fe (g dry tissue)-1. The mean total scan time at repetition time 1000 ms was 42% of that at repetition time 2500 ms. The repeatability coefficients for the two protocols were not significantly different from each other. A systematic difference in the measured R2 using each protocol was found indicating that an adjustment factor is required when one protocol is used to replace the other. The 95% limits of agreement between the two protocols were not significantly different from their repeatability coefficients indicating that the protocols can be interchanged without any significant change in accuracy or precision of liver iron concentration measurement. Magn Reson Med, 2011. [copy 2010 Wiley-Liss, Inc. The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin‐density‐projection‐assisted R2‐magnetic resonance imaging for the purpose of measuring liver iron concentration were evaluated. Repeated liver R2 measurements were made using both protocols on 60 subjects with liver iron concentrations ranging from 0.5 to 48.6 mg Fe (g dry tissue)−1. The mean total scan time at repetition time 1000 ms was 42% of that at repetition time 2500 ms. The repeatability coefficients for the two protocols were not significantly different from each other. A systematic difference in the measured R2 using each protocol was found indicating that an adjustment factor is required when one protocol is used to replace the other. The 95% limits of agreement between the two protocols were not significantly different from their repeatability coefficients indicating that the protocols can be interchanged without any significant change in accuracy or precision of liver iron concentration measurement. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc. |
Author | Aydinok, Yesim Ibrahim, Ahmed S. Pang, Wenjie Bayraktaroglu, Selen El‐Beshlawy, Amal St Pierre, Timothy G. Pavitt, Helen L. Sharples, Christopher Hamdy, Mona M. |
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References_xml | – volume: 21 start-page: 519 year: 2003 end-page: 530 article-title: Bi‐exponential proton transverse relaxation rate (R2) image analysis using RF field intensity‐weighted spin density projection: potential for R2 measurement of iron‐loaded liver publication-title: Magn Reson Imaging – volume: 363 start-page: 357 year: 2004 end-page: 362 article-title: Non‐invasive assessment of hepatic iron stores by MRI publication-title: Lancet – volume: 8 start-page: 599 year: 1990 end-page: 604 article-title: Prolonged T1 in patients with liver cirrhosis: an in vivo MRI study publication-title: Magn Reson Imaging – volume: 22 start-page: 2171 year: 2001 end-page: 2179 article-title: Cardiovascular T2‐star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload publication-title: Eur Heart J – volume: 8 start-page: 135 year: 1999 end-page: 160 article-title: Measuring agreement in method comparison studies publication-title: Stat Methods Med Res – volume: 113 start-page: 4853 year: 2009 end-page: 4855 article-title: R2* magnetic resonance imaging of the liver in patients with iron overload publication-title: Blood – volume: 28 start-page: 69 year: 2004 end-page: 76 article-title: Reduction of respiratory motion artifacts in transverse relaxation rate (R2) images of the liver publication-title: Comput Med Imaging Graph – volume: 17 start-page: 446 year: 2004 end-page: 458 article-title: Single spin‐echo proton transverse relaxometry of iron‐loaded liver publication-title: NMR Biomed – volume: 106 start-page: 1460 year: 2005 end-page: 1465 article-title: MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion‐dependent thalassemia and sickle cell disease patients publication-title: Blood – volume: 343 start-page: 327 year: 2000 end-page: 331 article-title: Hepatic iron concentration and total body iron stores in thalassemia major publication-title: N Engl J Med – volume: 126 start-page: 736 year: 2004 end-page: 742 article-title: Magnetic resonance imaging in the evaluation of iron overload in patients with beta thalassaemia and sickle cell disease publication-title: Br J Haematol – volume: 105 start-page: 855 year: 2005 end-page: 861 article-title: Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance publication-title: Blood |
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Snippet | The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin‐density‐projection‐assisted R2‐magnetic resonance imaging for the... The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin-density-projection-assisted R2-magnetic resonance imaging for the... |
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SubjectTerms | Adolescent Adult Aged beta-Thalassemia - pathology Child Egypt Female Humans iron overload Iron Overload - pathology Liver - pathology liver iron concentration magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Myelodysplastic Syndromes - pathology Reproducibility of Results Statistics, Nonparametric Time Factors Turkey |
Title | The effect of reducing repetition time TR on the measurement of liver R2 for the purpose of measuring liver iron concentration |
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