Relaxant responses to calcium channel antagonists and potassium channel opener in human saphenous vein

• Published in: Autonomic & autacoid pharmacology Vol. 26; no. 1; pp. 7 - 13
• Main Authors: Ford, C., Bieger, D., Mong, K., Tabrizchi, R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.01.2006
• Subjects: Calcium Channel Blockers - pharmacology; Calcium Channels, L-Type - drug effects; Calcium Channels, T-Type - drug effects; Dose-Response Relationship, Drug; excitation-contraction coupling; human vascular smooth muscle; Humans; In Vitro Techniques; L-type and T-type channels; membrane potential; Membrane Potentials; Mibefradil - pharmacology; Muscle, Smooth, Vascular - drug effects; Nifedipine - pharmacology; organic calcium channel antagonist; Pinacidil - pharmacology; potassium channels; Potassium Channels - agonists; Saphenous Vein - drug effects; Saphenous Vein - physiology; Vasodilation - drug effects; Vasodilator Agents - pharmacology

Summary 1 As shown in a parallel study the magnitude of depolarization induced in human saphenous vein by raising external potassium ([K+]e) falls markedly below the theoretical values predicted by the Goldman–Hodgkin–Katz equations. This anomaly prompted us to re‐examine the relaxant actions of L‐t...