Cerebrovascular accident during cisplatin-based combination chemotherapy of testicular germ cell tumor: an unusual case report

• Published in: Anti-cancer drugs Vol. 19; no. 1; p. 97
• Main Authors: Azak, Alper, Oksüzoğlu, Berna, Deren, Tağmaç, Oneç, Birgül Müftüoğlu, Zengin, Nurullah
• Format: Journal Article
• Language: English
• Published: England 01.01.2008
• Subjects: Adolescent; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Blood Coagulation Tests; Cerebral Infarction - chemically induced; Cerebral Infarction - etiology; Cisplatin - adverse effects; Cisplatin - therapeutic use; Fatal Outcome; Humans; Male; Neoplasms, Germ Cell and Embryonal - complications; Neoplasms, Germ Cell and Embryonal - drug therapy; Stroke - chemically induced; Stroke - etiology; Testicular Neoplasms - complications; Testicular Neoplasms - drug therapy; Thromboembolism - chemically induced; Thromboembolism - etiology; Tomography, X-Ray Computed
• ISSN: 0959-4973; 1473-5741
• DOI: 10.1097/CAD.0b013e3282f0777e

Even though testicular nonseminomatous germ cell tumors (NSGCTs) usually have a good prognosis and high curability rates, unpredicted complications owing to chemotherapy regimens might complicate the course. Modalities that are commonly used to cure NSGCTs have well-known side effects. Thromboembolism, which is infrequently associated with germ cell tumors and the vascular toxicity of chemotherapeutics, causes morbidity and mortality. We report a young testicular NSGCT patient, without any known underlying risk factor, who experienced an unpredicted cerebrovascular accident after he received cisplatin-based combination chemotherapy.