A Tumor‐Microenvironment‐Responsive Lanthanide–Cyanine FRET Sensor for NIR‐II Luminescence‐Lifetime In Situ Imaging of Hepatocellular Carcinoma

• Published in: Advanced materials (Weinheim) Vol. 32; no. 28; pp. e2001172 - n/a
• Main Authors: Zhao, Mengyao, Li, Benhao, Wu, Yifan, He, Haisheng, Zhu, Xinyan, Zhang, Hongxin, Dou, Chaoran, Feng, Lishuai, Fan, Yong, Zhang, Fan
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.07.2020
• Subjects: Attenuation; Energy transfer; hepatocellular carcinoma detection; lanthanides; Liver cancer; Magnetic resonance imaging; NIR‐II dyes; NIR‐II lifetime imaging; Penetration depth; Tumors

Deep tissue imaging in the second near‐infrared (NIR‐II) window holds great promise for widespread fundamental research. However, inhomogeneous signal attenuation due to tissue absorption and scattering hampers its application for accurate in vivo biosensing. Here, lifetime‐based in situ hepatocellu...