Protective Effects of Nucleosides‐Rich Extract from Cordyceps cicadae against Cisplatin Induced Testicular Damage

• Published in: Chemistry & biodiversity Vol. 17; no. 11; pp. e2000671 - n/a
• Main Authors: Wang, Ling, He, Yigang, Li, Yudi, Pei, Chengbin, Olatunji, Opeyemi Joshua, Tang, Jian, Famurewa, Ademola C., Wang, Hongyan, Yan, Bei
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.11.2020
• Subjects: Anticancer properties; Antioxidants; Body weight; Catalase; Chemotherapy; Cisplatin; Cordyceps; Cordyceps cicadae; Damage prevention; Follicle-stimulating hormone; Glutathione; Glutathione peroxidase; Histology; Inflammation; Interleukins; Malondialdehyde; Nucleosides; Oral administration; Oxidative stress; Peroxidase; Pretreatment; Superoxide dismutase; Testes; Testosterone; Toxicity; Tumor necrosis factor; Tumor necrosis factor-TNF

Cisplatin (CISP) is an efficacious anticancer agent used in chemotherapy, however, the constraint to its clinical utility is the stray organ toxicity including testicular damage linked to oxidative and inflammatory cascades. This study aimed to explore the protective effect of nucleosides‐rich extra...