A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death - Xu, Marvin Xuejun; Liu, Xinxin; Zhang, Hai-Liang; Xu, Hongyun; Ma, Xiangyu; Yang, Yupo; Duan, Chaoqun; Tang, Shanshun; Liu, Yaqing; Li, Cen; Pei, Mengfu; Xia, Junkai; et al. (British journal of pharmacology, 2025)
Keywords: Animals; Antineoplastic Agents - chemical synthesis; Cell Death - drug effects; Cell Line, Tumor; Female; Humans; Lysosomes - drug effects; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Random Allocation; STAT3 Transcription Factor - antagonists & inhibitors; Xenograft Model Antitumor Assays; RDp002; triple‐negative breast cancer (TNBC); STAT3 inhibitor; multiple myeloma (MM); lysosome‐dependent cell death