Large‐Scale Synthesis of Functionalized Nanowires to Construct Nanoelectrodes for Intracellular Sensing
A strategy for one‐pot and large‐scale synthesis of functionalized core–shell nanowires (NWs) to high‐efficiently construct single nanowire electrodes is proposed. Based on the polymerization reaction between 3,4‐ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticl...
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| Published in | Angewandte Chemie International Edition Vol. 60; no. 35; pp. 19337 - 19343 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Weinheim
Wiley Subscription Services, Inc
23.08.2021
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| Edition | International ed. in English |
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| Abstract | A strategy for one‐pot and large‐scale synthesis of functionalized core–shell nanowires (NWs) to high‐efficiently construct single nanowire electrodes is proposed. Based on the polymerization reaction between 3,4‐ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticles‐polyEDOT (PEDOT) nanocomposites can be uniformly modified on the surface of any nonconductive NWs. This provides a facile and versatile approach to produce massive number of core–shell NWs with excellent conductivity, adjustable size, and well‐designed properties. Nanoelectrodes manufactured with such core–shell NWs exhibit excellent electrochemical performance and mechanical stability as well as favorable antifouling properties, which are demonstrated by in situ intracellular monitoring of biological molecules (nitric oxide) and unraveling its relevant unclear signaling pathway inside single living cells.
Versatile one‐pot synthesis of functionalized core–shell nanowires breaks through the limitation of nanoelectrode materials to facilely construct high‐performance single nanowire electrodes. Concurrently with excellent electrochemical, mechanical, and antifouling properties, the nanowire electrodes show great superiority in real‐time monitoring of biological molecules and unraveling the relevant signaling pathway inside single living cells. |
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| AbstractList | A strategy for one-pot and large-scale synthesis of functionalized core-shell nanowires (NWs) to high-efficiently construct single nanowire electrodes is proposed. Based on the polymerization reaction between 3,4-ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticles-polyEDOT (PEDOT) nanocomposites can be uniformly modified on the surface of any nonconductive NWs. This provides a facile and versatile approach to produce massive number of core-shell NWs with excellent conductivity, adjustable size, and well-designed properties. Nanoelectrodes manufactured with such core-shell NWs exhibit excellent electrochemical performance and mechanical stability as well as favorable antifouling properties, which are demonstrated by in situ intracellular monitoring of biological molecules (nitric oxide) and unraveling its relevant unclear signaling pathway inside single living cells.A strategy for one-pot and large-scale synthesis of functionalized core-shell nanowires (NWs) to high-efficiently construct single nanowire electrodes is proposed. Based on the polymerization reaction between 3,4-ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticles-polyEDOT (PEDOT) nanocomposites can be uniformly modified on the surface of any nonconductive NWs. This provides a facile and versatile approach to produce massive number of core-shell NWs with excellent conductivity, adjustable size, and well-designed properties. Nanoelectrodes manufactured with such core-shell NWs exhibit excellent electrochemical performance and mechanical stability as well as favorable antifouling properties, which are demonstrated by in situ intracellular monitoring of biological molecules (nitric oxide) and unraveling its relevant unclear signaling pathway inside single living cells. A strategy for one‐pot and large‐scale synthesis of functionalized core–shell nanowires (NWs) to high‐efficiently construct single nanowire electrodes is proposed. Based on the polymerization reaction between 3,4‐ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticles‐polyEDOT (PEDOT) nanocomposites can be uniformly modified on the surface of any nonconductive NWs. This provides a facile and versatile approach to produce massive number of core–shell NWs with excellent conductivity, adjustable size, and well‐designed properties. Nanoelectrodes manufactured with such core–shell NWs exhibit excellent electrochemical performance and mechanical stability as well as favorable antifouling properties, which are demonstrated by in situ intracellular monitoring of biological molecules (nitric oxide) and unraveling its relevant unclear signaling pathway inside single living cells. Versatile one‐pot synthesis of functionalized core–shell nanowires breaks through the limitation of nanoelectrode materials to facilely construct high‐performance single nanowire electrodes. Concurrently with excellent electrochemical, mechanical, and antifouling properties, the nanowire electrodes show great superiority in real‐time monitoring of biological molecules and unraveling the relevant signaling pathway inside single living cells. A strategy for one‐pot and large‐scale synthesis of functionalized core–shell nanowires (NWs) to high‐efficiently construct single nanowire electrodes is proposed. Based on the polymerization reaction between 3,4‐ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticles‐polyEDOT (PEDOT) nanocomposites can be uniformly modified on the surface of any nonconductive NWs. This provides a facile and versatile approach to produce massive number of core–shell NWs with excellent conductivity, adjustable size, and well‐designed properties. Nanoelectrodes manufactured with such core–shell NWs exhibit excellent electrochemical performance and mechanical stability as well as favorable antifouling properties, which are demonstrated by in situ intracellular monitoring of biological molecules (nitric oxide) and unraveling its relevant unclear signaling pathway inside single living cells. |
| Author | Huang, Wei‐Hua Yan, Jing Jiang, Hong Qi, Yu‐Ting Liu, Yan‐Ling Fan, Wen‐Ting Wu, Wen‐Tao |
| Author_xml | – sequence: 1 givenname: Wen‐Tao surname: Wu fullname: Wu, Wen‐Tao organization: Wuhan University – sequence: 2 givenname: Hong surname: Jiang fullname: Jiang, Hong organization: Wuhan University – sequence: 3 givenname: Yu‐Ting surname: Qi fullname: Qi, Yu‐Ting organization: Wuhan University – sequence: 4 givenname: Wen‐Ting surname: Fan fullname: Fan, Wen‐Ting organization: Wuhan University – sequence: 5 givenname: Jing surname: Yan fullname: Yan, Jing organization: Wuhan University – sequence: 6 givenname: Yan‐Ling orcidid: 0000-0002-7386-354X surname: Liu fullname: Liu, Yan‐Ling organization: Wuhan University – sequence: 7 givenname: Wei‐Hua orcidid: 0000-0001-8951-075X surname: Huang fullname: Huang, Wei‐Hua email: whhuang@whu.edu.cn organization: Wuhan University |
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| Snippet | A strategy for one‐pot and large‐scale synthesis of functionalized core–shell nanowires (NWs) to high‐efficiently construct single nanowire electrodes is... A strategy for one-pot and large-scale synthesis of functionalized core-shell nanowires (NWs) to high-efficiently construct single nanowire electrodes is... |
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| SubjectTerms | Antifouling substances Biomonitoring Cations Electrochemical analysis Electrochemistry glucocorticoids Intracellular Metal ions Nanocomposites nanoelectrode Nanoparticles Nanotechnology nanowire Nanowires Nitric oxide Noble metals Signal transduction single cell Synthesis |
| Title | Large‐Scale Synthesis of Functionalized Nanowires to Construct Nanoelectrodes for Intracellular Sensing |
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