Carrier Free Photodynamic Synergists for Oxidative Damage Amplified Tumor Therapy

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 17; no. 40; pp. e2102470 - n/a
• Main Authors: Li, Xin‐Yu, Deng, Fu‐An, Zheng, Rong‐Rong, Liu, Ling‐Shan, Liu, Yi‐Bin, Kong, Ren‐Jiang, Chen, A‐Li, Yu, Xi‐Yong, Li, Shi‐Ying, Cheng, Hong
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.10.2021
• Subjects: Anticancer properties; Chlorine; Hydrophobicity; Lethality; Light irradiation; Loading rate; MTH1 inhibition; nanoplatform; Nanotechnology; Oxidation resistance; oxidative damage; Photodynamic therapy; Radiation damage; self‐delivery; Size distribution; Toxicity

Tumor cells adapt to excessive oxidative stress by actuating reactive oxygen species (ROS)‐defensing system, leading to a resistance to oxidation therapy. In this work, self‐delivery photodynamic synergists (designated as PhotoSyn) are developed for oxidative damage amplified tumor therapy. Specific...