Histone deacetylases and mechanisms of regulation of gene expression

• Published in: Critical reviews in oncogenesis Vol. 20; no. 1-2; p. 35
• Main Authors: Chen, Hong Ping, Zhao, Yu Tina, Zhao, Ting C
• Format: Journal Article
• Language: English
• Published: United States 2015
• Subjects: Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Colonic Neoplasms - genetics; Colonic Neoplasms - metabolism; Female; Gene Expression Regulation - drug effects; Hematologic Neoplasms - genetics; Hematologic Neoplasms - metabolism; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylases - physiology; Humans; Inflammation - genetics; Inflammation - metabolism; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Male; Urogenital Neoplasms - genetics; Urogenital Neoplasms - metabolism

In recent years it has become widely recognized that histone modification plays a pivotal role in controlling gene expression and is involved in a wide spectrum of disease regulation. Histone acetylation is a major modification that affects gene transcription and is controlled by histone acetyltrans...