3′-UTR polymorphism of dopamine transporter gene in Hadza and Datoga males
A study of VNTR polymorphism and molecular structure of 3′-UTR of the dopamine transporter gene ( DAT1 / SLC6A3 ) was performed in the Hadza and Datoga males. It was shown that Hadza and Datoga differed in allele and genotype frequencies. Allele with 9 repeats in 3′-UTR, as well as the DAT1 homozygo...
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Published in | Molecular biology (New York) Vol. 48; no. 2; pp. 254 - 257 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Moscow
Pleiades Publishing
01.03.2014
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | A study of VNTR polymorphism and molecular structure of 3′-UTR of the dopamine transporter gene (
DAT1
/
SLC6A3
) was performed in the Hadza and Datoga males. It was shown that Hadza and Datoga differed in allele and genotype frequencies. Allele with 9 repeats in 3′-UTR, as well as the
DAT1
homozygous genotype 9/9, is more common in the Hadza. The allele with ten repeats, as well as the homozygous phenotype 10/10, is more common in the Datoga. Molecular structure of
DAT1
alleles with 3, 8, and 12 repeats was determined for the first time. In addition, it was found that the
DAT1
allele with 11 repeats in the Datoga significantly differed in the type and arrangement of repeats from those previously described in other populations. We suggest that variations in the repeats number and type in the 3′-UTR of allelic variants may affect the dopamine transporter gene function. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0026-8933 1608-3245 |
DOI: | 10.1134/S0026893314020174 |