Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice

• Published in: Mutation research Vol. 561; no. 1-2; pp. 127 - 138
• Main Authors: Mittelstaedt, Roberta A., Mei, Nan, Webb, Peggy J., Shaddock, Joseph G., Dobrovolsky, Vasily N., McGarrity, Lynda J., Morris, Suzanne M., Chen, Tao, Beland, Frederick A., Greenlees, Kevin J., Heflich, Robert H.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 11.07.2004
• Subjects: Analysis of Variance; Aniline Compounds - toxicity; Animals; Base Sequence; Biological and medical sciences; DNA Adducts - drug effects; Erythrocytes - drug effects; Female; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Liver - drug effects; Liver - metabolism; Lymphocytes - drug effects; Lymphocytes - metabolism; Medical sciences; Mice; Mice, Transgenic; Micronuclei, Chromosome-Defective - drug effects; Mutagenicity Tests; Mutation - drug effects; Rosaniline Dyes - toxicity; Time Factors; Toxicology; Transcription Factors - genetics; Viral Proteins; Toxicity; Rodentia; Genotoxicity; Transgenic animal; Triarylmethane dye; Hprt mutation assay; cll mutation assay; Mouse micronucleus assay; Vertebrata; Toxicology; Mammalia; Mouse; Micronucleus; Female; Genetics; Leucomalachite green; Mutation; Malachite green

Malachite green, a triphenylmethane dye used in aquaculture as an antifungal agent, is rapidly reduced in vivo to leucomalachite green. Previous studies in which female B6C3F1 mice were fed malachite green produced relatively high levels of liver DNA adducts after 28 days, but no significant inducti...