One-Stage Pathway from Hollongdione to C17-Alkyne and Vinyl Chloride Following Mannich Bases and Carboxylic Acid

• Published in: International journal of molecular sciences Vol. 25; no. 15; p. 8356
• Main Authors: Galimova, Zarema, Smirnova, Irina, Lobov, Alexander, Polovyanenko, Dmitriy, Rybalova, Tatyana, Kazakova, Oxana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2024
• Subjects: alkyne; Alkynes - chemistry; Carboxylic Acids - chemistry; Catalysis; dammarane triterpenoids; hollongdione; hollongdionoic acid; Magnetic Resonance Spectroscopy; Mannich base; Mannich Bases - chemistry; Molecular Structure; Triterpenes - chemistry; Vinyl chloride; Vinyl Chloride - chemistry; alkyne; vinyl chloride; hollongdione; Mannich base; dammarane triterpenoids; hollongdionoic acid

Hollongdione is the first recorded example of the occurrence of a dammarane hexanor-triterpene in nature possessing antiviral and cytotoxic activity. Its simple one-stage transformation into compounds with terminal alkyne and vinyl chloride fragments via the interaction with phosphorus halides is re...