Circulatory models in assessment of cardiac enzyme release in dogs
Cardiac ischemia causes interstitial leakage of cellular enzymes followed by release of these enzymes into plasma. Quantitative interpretation of these data requires a specific circulatory model, and the performance of such models was investigated. Plasma activities of cardiac enzymes were measured...
Saved in:
Published in | The American journal of physiology Vol. 264; no. 3 Pt 2; p. H747 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.03.1993
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Cardiac ischemia causes interstitial leakage of cellular enzymes followed by release of these enzymes into plasma. Quantitative interpretation of these data requires a specific circulatory model, and the performance of such models was investigated. Plasma activities of cardiac enzymes were measured for increasingly abrupt forms of ischemic heart injury in the dog: 1) permanent ligation of the left anterior descending coronary artery (LAD); 2) reperfusion after 2 h of ligation of the LAD; and 3) calcium-free perfusion of the LAD during 10 min (calcium-paradox injury). Release into plasma of a rapidly (41%/h) and a slowly (2.2%/h) catabolized enzyme was calculated from the plasma activities, using a detailed circulatory model with compartments for heart, plasma, muscle, skin, and viscera. The time course of cellular enzyme leakage into interstitial space in the heart was calculated from release into plasma and a range of reported values for transendothelial permeability. Simplification to one- and two-compartment models introduced, respectively, 10 and 2% error in calculated cumulative release. Considering the other sources of error, this implies adequate performance of the two-compartment model. Protein washout from the heart is strongly influenced by expansion of interstitial protein space with dead myocyte volume and depends on the microheterogeneity of necrotic tissue areas. Accelerated release of enzymes into plasma after reperfusion reflects accelerated cellular leakage rather than enhanced washout. |
---|---|
AbstractList | Cardiac ischemia causes interstitial leakage of cellular enzymes followed by release of these enzymes into plasma. Quantitative interpretation of these data requires a specific circulatory model, and the performance of such models was investigated. Plasma activities of cardiac enzymes were measured for increasingly abrupt forms of ischemic heart injury in the dog: 1) permanent ligation of the left anterior descending coronary artery (LAD); 2) reperfusion after 2 h of ligation of the LAD; and 3) calcium-free perfusion of the LAD during 10 min (calcium-paradox injury). Release into plasma of a rapidly (41%/h) and a slowly (2.2%/h) catabolized enzyme was calculated from the plasma activities, using a detailed circulatory model with compartments for heart, plasma, muscle, skin, and viscera. The time course of cellular enzyme leakage into interstitial space in the heart was calculated from release into plasma and a range of reported values for transendothelial permeability. Simplification to one- and two-compartment models introduced, respectively, 10 and 2% error in calculated cumulative release. Considering the other sources of error, this implies adequate performance of the two-compartment model. Protein washout from the heart is strongly influenced by expansion of interstitial protein space with dead myocyte volume and depends on the microheterogeneity of necrotic tissue areas. Accelerated release of enzymes into plasma after reperfusion reflects accelerated cellular leakage rather than enhanced washout. |
Author | van der Veen, F H Willems, G M Hermens, W T van Kreel, B K |
Author_xml | – sequence: 1 givenname: B K surname: van Kreel fullname: van Kreel, B K organization: Department of Clinical Chemistry, University Hospital Maastricht, The Netherlands – sequence: 2 givenname: F H surname: van der Veen fullname: van der Veen, F H – sequence: 3 givenname: G M surname: Willems fullname: Willems, G M – sequence: 4 givenname: W T surname: Hermens fullname: Hermens, W T |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8456977$$D View this record in MEDLINE/PubMed |
BookMark | eNotj81Kw0AUhWdRqW31EYR5gcT5T7LUoLZQcKPrcjP3RlPyx0y6iE9vxK4OBz4O39myVT_0xBiXIpXSqkc4j98EYUplUehUOZPqdJ-ZbMU2QgiVFFbqW7aN8bxUabVZs3VurCuybMOeyyb4SwvTEGbeDUht5E3PIUaKsaN-4kPNPQRswHPqf-aOeKCWINIfh8NXvGM3NbSR7q-5Y5-vLx_lPjm-vx3Kp2PitSmmpDK6ltohVE5pSeRzcLnwVkqBNlvUUQklc1Korc4dologocGjRLXIqh17-N8dL1VHeBpD00GYT9cv6hfGaU44 |
CitedBy_id | crossref_primary_10_1152_ajpheart_01207_2004 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1152/ajpheart.1993.264.3.H747 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
ExternalDocumentID | 8456977 |
Genre | Journal Article |
GroupedDBID | -DZ -~X .55 .GJ 23M 3O- 41~ 53G 5GY 79B 85S 8M5 9M8 ABCQX ABJNI ABOCM ABPPZ ABTAH ACGFS ACGUR ACKIV ACNCT ACPRK AFFDN AFFNX AI. ALMA_UNASSIGNED_HOLDINGS BKKCC CGR CUY CVF D0L EBS ECM EIF EJD F20 F5P G8K H13 IH2 ITBOX J5H L7B LPU MVM NEJ NHB NPM OHT PQQKQ RAP RHI RPL SJN TWZ UHB UKR UQL VH1 WH7 X7M XOL YYP YZZ ZGI ZXP ZY4 |
ID | FETCH-LOGICAL-c349t-b43f136dab6231eec8a680c5110d57993d20218e2d35386dd21ee03acd1d26972 |
ISSN | 0002-9513 |
IngestDate | Sat Sep 28 08:49:26 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 Pt 2 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c349t-b43f136dab6231eec8a680c5110d57993d20218e2d35386dd21ee03acd1d26972 |
PMID | 8456977 |
ParticipantIDs | pubmed_primary_8456977 |
PublicationCentury | 1900 |
PublicationDate | 1993-03-01 |
PublicationDateYYYYMMDD | 1993-03-01 |
PublicationDate_xml | – month: 03 year: 1993 text: 1993-03-01 day: 01 |
PublicationDecade | 1990 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The American journal of physiology |
PublicationTitleAlternate | Am J Physiol |
PublicationYear | 1993 |
SSID | ssj0001534 |
Score | 1.5192264 |
Snippet | Cardiac ischemia causes interstitial leakage of cellular enzymes followed by release of these enzymes into plasma. Quantitative interpretation of these data... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | H747 |
SubjectTerms | Alanine Transaminase - blood Animals Coronary Vessels - surgery Dogs Female Hydroxybutyrate Dehydrogenase - blood Kinetics Ligation Male Models, Biological Myocardial Ischemia - enzymology Myocardial Reperfusion Injury - enzymology Myocardium - enzymology |
Title | Circulatory models in assessment of cardiac enzyme release in dogs |
URI | https://www.ncbi.nlm.nih.gov/pubmed/8456977 |
Volume | 264 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwELbKIhAXxFOwLMgHtJcq3TR2HOcICKhAIA6w4oYc25FAalpVuQB_fmds04QCguUSRXZqxfm-jsfjeRCyz42WUqUiymMVR7wwPFJcFlFWos-iUFwbl-3zUgxu-NltetvpPLejS-qip5_ejSv5DqrQBrhilOx_IDsdFBrgHvCFKyAM1y9hfHQ_QTdSd07uSto451Y1TbbpfMYdBXTXVk-PQ18jBRYu5wQ7Cjbyh4Yx0wOcVkYJZ_x4ZX3HmKfzifUH_IeNpRTbMTfF31Dt_qQJfUC7jvVmndO2BXYC7-kd_YK7tgkheaxxwWpJVdDUWFuqJj45eaAP617V3aQlKAeZT7T5VoKnmBFWPYyxoHeNwZSsB2P1WG_2J4DFeOiQlaAF5tnnnTOZtUPPHJnLJArHSzT0hEUcFgL-snPCqb04gaXJn4_ebYkshBFntihOVbleIcthj0EPPGFWScdWa2T9oAKiDB_pb3o1BXSNLF4E54p1ctiiE_V0ovcVbehERyUNdKKeTjTQCZ9DOm2Qm5Pj66NBFEpsRJrxvI4Kzso-E0YVoAb3rdVSCRlr0MJjk2YwP5OgEmgTw2BlFMYk8FDMlDZ9k8BUk03yoxpVdotQ0LsZt7mQshRcmTy3mPjd5MLqFEYstsmm_yh3Y59H5S58rZ8fdeyQpYZuv8h8CX9buws6YF3sObT-Ad4GWME |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Circulatory+models+in+assessment+of+cardiac+enzyme+release+in+dogs&rft.jtitle=The+American+journal+of+physiology&rft.au=van+Kreel%2C+B+K&rft.au=van+der+Veen%2C+F+H&rft.au=Willems%2C+G+M&rft.au=Hermens%2C+W+T&rft.date=1993-03-01&rft.issn=0002-9513&rft.volume=264&rft.issue=3+Pt+2&rft.spage=H747&rft_id=info:doi/10.1152%2Fajpheart.1993.264.3.H747&rft_id=info%3Apmid%2F8456977&rft_id=info%3Apmid%2F8456977&rft.externalDocID=8456977 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9513&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9513&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9513&client=summon |