Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implications

• Published in: Current Issues in Molecular Biology Vol. 46; no. 7; pp. 7324 - 7338
• Main Authors: Pan, Xingli, Gao, Yuxin, Guan, Kaifu, Chen, Jing, Ji, Bingyuan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2024
• Subjects: Animal behavior; Antidepressants; cell signaling; depression; Depression, Mental; Development and progression; ghrelin; GHSR; GPCR; Health aspects; Insomnia; Neural networks; China; GHSR; GPCR; ghrelin; depression; cell signaling

Depression is the most common chronic mental illness and is characterized by low mood, insomnia, and affective disorders. However, its pathologic mechanisms remain unclear. Numerous studies have suggested that the ghrelin/GHSR system may be involved in the pathophysiologic process of depression. Ghr...