Two NOTCH4 polymorphisms and their relation to schizophrenia susceptibility and different personality traits

• Published in: Psychiatric genetics Vol. 13; no. 1; p. 23
• Main Authors: Carmine, Andrea, Chheda, Milan G, Jönsson, Erik G, Sedvall, Göran C, Farde, Lars, Gustavsson, J Petter, Bergman, Hans, Anvret, Maria, Buervenich, Silvia, Olson, Lars
• Format: Journal Article
• Language: English
• Published: England 01.03.2003
• Subjects: Biogenic Monoamines - cerebrospinal fluid; Disease Susceptibility; European Continental Ancestry Group; Female; Genetic Variation; Genotype; Humans; Major Histocompatibility Complex - genetics; Male; Mutation, Missense; Personality - genetics; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins - genetics; Receptor, Notch4; Receptors, Cell Surface; Receptors, Notch; Reference Values; Schizophrenia - genetics; Surveys and Questionnaires; Sweden; Tomography, Emission-Computed

Recently, linkage disequilibrium mapping of the major histocompatibility complex region on the short arm of human chromosome 6 suggested that the NOTCH4 locus is highly associated with schizophrenia. We analysed two polymorphisms in this gene in Swedish schizophrenic patients ( =74) and control subj...