Analysis of HSPA1B A1267G gene polymorphism in peptic ulcer
Peptic ulcer disease (PUD) is a common illness, affecting a considerable number of people world-wide, and its occurrence can be influenced by environmental and genetic factors. Heat shock proteins (HSPs) function mostly as molecular chaperones, and are induced by various stresses. The A to G transit...
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| Published in | Molecular biology (New York) Vol. 48; no. 5; pp. 634 - 637 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Moscow
Pleiades Publishing
01.09.2014
Springer Nature B.V |
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| Abstract | Peptic ulcer disease (PUD) is a common illness, affecting a considerable number of people world-wide, and its occurrence can be influenced by environmental and genetic factors. Heat shock proteins (HSPs) function mostly as molecular chaperones, and are induced by various stresses. The A to G transition at position 1267 of the
HSPA1B
gene was shown to correlate with changes in the level of HSPA mRNA expression. Here, the relation between A1267G polymorphism of the
HSPA1B
gene and risk of peptic ulcer in the Iranian population was evaluated. One hundred subjects, who underwent gastroscopy, took part in the study. DNA samples extracted from the biopsy tissues were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). After gastroscopy, peptic ulcer was diagnosed for 50 patients; among them the distribution of AA/AB/BB genotypes was 10, 88, and 2%, respectively. As for the other 50 subjects (without peptic ulcer) included in the control group, the AA/AB/BB genotypes were identified as 40, 52 and 8%, respectively. A significant association was found between the
HSPA1B
genotype and peptic ulcer (6.76 OR; 95% CI, 2.26–20.2;
p
= 0.0006). Thus, the
HSPA1B
A1267G polymorphism may be a marker of susceptibility to peptic ulcer. |
|---|---|
| AbstractList | Peptic ulcer disease (PUD) is a common illness, affecting a considerable number of people world-wide, and its occurrence can be influenced by environmental and genetic factors. Heat shock proteins (HSPs) function mostly as molecular chaperones, and are induced by various stresses. The A to G transition at position 1267 of the HSPA1B gene was shown to correlate with changes in the level of HSPA mRNA expression. Here, the relation between A1267G polymorphism of the HSPA1B gene and risk of peptic ulcer in the Iranian population was evaluated. One hundred subjects, who underwent gastroscopy, took part in the study. DNA samples extracted from the biopsy tissues were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). After gastroscopy, peptic ulcer was diagnosed for 50 patients; among them the distribution of AA/AB/BB genotypes was 10, 88, and 2%, respectively. As for the other 50 subjects (without peptic ulcer) included in the control group, the AA/AB/BB genotypes were identified as 40, 52 and 8%, respectively. A significant association was found between the HSPA1B genotype and peptic ulcer (6.76 OR; 95% CI, 2.26-20.2; p = 0.0006). Thus, the HSPA1B A1267G polymorphism may be a marker of susceptibility to peptic ulcer. Peptic ulcer disease (PUD) is a common illness, affecting a considerable number of people world-wide, and its occurrence can be influenced by environmental and genetic factors. Heat shock proteins (HSPs) function mostly as molecular chaperones, and are induced by various stresses. The A to G transition at position 1267 of the HSPA1B gene was shown to correlate with changes in the level of HSPA mRNA expression. Here, the relation between A1267G polymorphism of the HSPA1B gene and risk of peptic ulcer in the Iranian population was evaluated. One hundred subjects, who underwent gastroscopy, took part in the study. DNA samples extracted from the biopsy tissues were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). After gastroscopy, peptic ulcer was diagnosed for 50 patients; among them the distribution of AA/AB/BB genotypes was 10, 88, and 2%, respectively. As for the other 50 subjects (without peptic ulcer) included in the control group, the AA/AB/BB genotypes were identified as 40, 52 and 8%, respectively. A significant association was found between the HSPA1B genotype and peptic ulcer (6.76 OR; 95% CI, 2.26-20.2; p = 0.0006). Thus, the HSPA1B A1267G polymorphism may be a marker of susceptibility to peptic ulcer.[PUBLICATION ABSTRACT] Peptic ulcer disease (PUD) is a common illness, affecting a considerable number of people world-wide, and its occurrence can be influenced by environmental and genetic factors. Heat shock proteins (HSPs) function mostly as molecular chaperones, and are induced by various stresses. The A to G transition at position 1267 of the HSPA1B gene was shown to correlate with changes in the level of HSPA mRNA expression. Here, the relation between A1267G polymorphism of the HSPA1B gene and risk of peptic ulcer in the Iranian population was evaluated. One hundred subjects, who underwent gastroscopy, took part in the study. DNA samples extracted from the biopsy tissues were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). After gastroscopy, peptic ulcer was diagnosed for 50 patients; among them the distribution of AA/AB/BB genotypes was 10, 88, and 2%, respectively. As for the other 50 subjects (without peptic ulcer) included in the control group, the AA/AB/BB genotypes were identified as 40, 52 and 8%, respectively. A significant association was found between the HSPA1B genotype and peptic ulcer (6.76 OR; 95% CI, 2.26–20.2; p = 0.0006). Thus, the HSPA1B A1267G polymorphism may be a marker of susceptibility to peptic ulcer. |
| Author | Ejtehadi, F. Ghorbani, M. J. Eskafi Sabet, E. Salehi, Z. |
| Author_xml | – sequence: 1 givenname: M. J. surname: Ghorbani fullname: Ghorbani, M. J. email: geneticzs@yahoo.co.uk organization: Department of Biology, International Pardis, University of Guilan – sequence: 2 givenname: Z. surname: Salehi fullname: Salehi, Z. organization: Department of Biology, Faculty of Sciences, University of Guilan – sequence: 3 givenname: E. surname: Eskafi Sabet fullname: Eskafi Sabet, E. organization: Department of Biology, Faculty of Sciences, University of Guilan – sequence: 4 givenname: F. surname: Ejtehadi fullname: Ejtehadi, F. organization: Internal Medicine Department, Shiraz University of Medical Sciences |
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| Cites_doi | 10.1196/annals.1354.040 10.1007/s00439-003-1050-1 10.1007/s12192-008-0068-7 10.1007/s10620-008-0313-z 10.1056/NEJM199906173402407 10.1038/ncpgasthep0393 10.1016/j.mad.2005.03.007 10.1111/j.1365-3083.1993.tb02593.x 10.1111/j.1432-1033.1994.tb19910.x 10.4103/0974-777X.91061 10.1136/ard.2009.122630 10.1016/S0304-3835(02)00697-3 10.1111/j.1572-0241.2004.30272.x 10.1016/0014-5793(96)00730-2 10.1007/s12192-007-0001-5 10.1002/pmic.200400951 10.1016/j.jscs.2012.03.002 10.1007/BF00187095 10.3949/ccjm.72.Suppl_2.S1 10.1038/ng2109 10.1056/NEJM199409153311107 10.1073/pnas.82.19.6455 10.1007/s001340051329 10.1093/hmg/ddq418 10.1002/jlb.51.2.181 |
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