Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition

• Published in: Molecular and cellular endocrinology Vol. 451; pp. 1 - 14
• Main Authors: Groner, Bernd, von Manstein, Viktoria
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.08.2017
• Subjects: Antineoplastic Agents - therapeutic use; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Immune therapy; Immunotherapy - methods; Jak stat signaling in cancer; Janus Kinases - antagonists & inhibitors; Janus Kinases - genetics; Janus Kinases - immunology; Molecular Targeted Therapy; Neoplasm Invasiveness; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - pathology; Neoplasms - therapy; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - immunology; Neoplastic Stem Cells - pathology; Signal Transduction; Signaling pathway interactions; STAT Transcription Factors - antagonists & inhibitors; STAT Transcription Factors - genetics; STAT Transcription Factors - immunology; Targeted therapeutics; Tumor microenvironment; Tumor Microenvironment - drug effects; Immune therapy; Targeted therapeutics; Signaling pathway interactions; Tumor microenvironment; Jak stat signaling in cancer

The effects of Jak Stat signaling and the persistent activation of Stat3 and Stat5 on tumor cell survival, proliferation and invasion have made the Jak Stat pathway a favorite target for drug development and cancer therapy. This notion was strengthened when additional biological functions of Stat si...