Mechanism of Gastroprotection by Bismuth Subsalicylate Against Chemically Induced Oxidative Stress in Cultured Human Gastric Mucosal Cells

• Published in: Digestive diseases and sciences Vol. 44; no. 12; pp. 2419 - 2428
• Main Authors: Bagchi, Debasis, McGinn, Thomas R., Ye, Xumein, Balmoori, Jaya, Bagchi, Manashi, Stohs, Sidney J., Kuszynski, Charles A., Carryl, Owen R., Mitra, Sekhar
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.12.1999; Springer Nature B.V
• Subjects: Biological and medical sciences; Bismuth - pharmacology; Cells, Cultured; Cytochrome c Group - metabolism; Digestive system; DNA Damage - drug effects; DNA Fragmentation - drug effects; Ethanol - pharmacology; Gastric Mucosa - cytology; Gastric Mucosa - drug effects; Gastric Mucosa - metabolism; Humans; Hydrochloric Acid - pharmacology; Medical sciences; Microscopy, Confocal; Organometallic Compounds - pharmacology; Oxidative Stress - drug effects; Pharmacology. Drug treatments; Reactive Oxygen Species; Salicylates - pharmacology; Sodium Hydroxide - pharmacology; Stomach - drug effects; Superoxides - metabolism; Human; Cell culture; Stomach; Oxidative stress; Bismuth compound; Metabolic diseases; Acetylsalicylic acid; Experimental study; Biological activity; Chemotherapy; Cytoprotector; Digestive diseases; Mechanism of action; Gastric disease

Reactive oxygen species (ROS) are implicated in the pathogenesis of chemically induced gastric mucosal injury. We have investigated the effects of ethanol, hydrochloric acid (HCl), and sodium hydroxide (NaOH) on: (1) enhanced production of ROS including superoxide anion and hydroxyl radicals, (2) mo...