Antigen receptor signaling: integration of protein tyrosine kinase functions

• Published in: Oncogene Vol. 17; no. 11; pp. 1353 - 1364
• Main Authors: Tamir, Idan, Cambier, John C
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 17.09.1998
• Subjects: Animals; Antigens; Apoptosis; B-cell receptor; Cell activation; Cell death; Cell differentiation; Cell survival; Enzymatic activity; Enzyme Precursors - metabolism; Genes, ras; Homology; Humans; Intracellular Signaling Peptides and Proteins; Lymphocytes B; Phosphorylation; Protein-tyrosine kinase; Protein-Tyrosine Kinases - metabolism; Receptor mechanisms; Receptors, Antigen - metabolism; Signal Transduction; src-Family Kinases - metabolism; Syk Kinase; ZAP-70 Protein-Tyrosine Kinase

Antigen receptors on T and B cells function to transduce signals leading to a variety of biologic responses minimally including antigen receptor editing, apoptotic death, developmental progression, cell activation, proliferation and survival. The response to antigen depends upon antigen affinity and...