Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy

• Published in: AIDS research and human retroviruses Vol. 23; no. 3; p. 381
• Main Authors: Persaud, Deborah, Ray, Stuart C, Kajdas, Joleen, Ahonkhai, Aima, Siberry, George K, Ferguson, Kimberly, Ziemniak, Carrie, Quinn, Thomas C, Casazza, Joseph P, Zeichner, Steven, Gange, Stephen J, Watson, Douglas C
• Format: Journal Article
• Language: English
• Published: United States 01.03.2007
• Subjects: Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes - virology; Child, Preschool; Drug Administration Schedule; Evolution, Molecular; Genes, env - genetics; Genes, pol - genetics; HIV Infections - drug therapy; HIV-1 - drug effects; HIV-1 - genetics; HIV-1 - physiology; Humans; Infant; Infant, Newborn; Longitudinal Studies; Phylogeny; RNA, Viral - blood; Viral Load; Virus Latency - genetics; Virus Latency - physiology; Virus Replication - physiology

A longitudinal study of viral reservoirs in children initiating highly active antiretroviral therapy (HAART) in early infancy was undertaken to test the hypothesis that early effective treatment affects the persistence of replication-competent viral latency and the evolution of HIV-1 in resting CD4(...