Pannexin-1 channels and their emerging functions in cardiovascular diseases

• Published in: Acta biochimica et biophysica Sinica Vol. 47; no. 6; pp. 391 - 396
• Main Authors: Li, Lanfang, He, Lu, Wu, Di, Chen, Linxi, Jiang, Zhisheng
• Format: Journal Article
• Language: English
• Published: China 01.06.2015
• Subjects: Cardiovascular Diseases - physiopathology; Humans; Nerve Tissue Proteins - physiology; 三磷酸腺苷; 循环系统; 心肌纤维化; 心血管疾病; 渠道; 生理功能; 细胞外; 膜通道; Pannexin-1; cardiac fibrosis; ATP; arrhythmia

Pannexin-1, Pannexin-2, and Pannexin-3 are three members of the Pannexin family of channel-forming glycoprotein. Their primary function is defined by their ability to form single-membrane channels. Pannexin-1 ubiquitously exists in many cells and organs throughout the body and is specially distribut...