Pannexin-1 channels and their emerging functions in cardiovascular diseases
Pannexin-1, Pannexin-2, and Pannexin-3 are three members of the Pannexin family of channel-forming glycoprotein. Their primary function is defined by their ability to form single-membrane channels. Pannexin-1 ubiquitously exists in many cells and organs throughout the body and is specially distribut...
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| Published in | Acta biochimica et biophysica Sinica Vol. 47; no. 6; pp. 391 - 396 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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China
01.06.2015
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| Abstract | Pannexin-1, Pannexin-2, and Pannexin-3 are three members of the Pannexin family of channel-forming glycoprotein. Their primary function is defined by their ability to form single-membrane channels. Pannexin-1 ubiquitously exists in many cells and organs throughout the body and is specially distributed in the circulatory system, while the expressions of Pannexin-2 and Pannexin-3 are mostly restricted to organs and tissues. Pannexin-1 oligomers have been shown to be functional single membrane channels that connect intracellular and extracellular compartments and are not intercellular channels in appositional membranes. The physiological functions of Pannexin-1 are to link to the adenosine triphosphate efflux that acts as a paracrine signal, and regulate cellular inflammasomes in a variety of cell types under physiological and pathophysiological conditions. However, there are still many functions to be explored. This review summarizes recent reports and discusses the role of Pannexin-1 in cardiovascular diseases, including ischemia, arrhythmia, cardiac fibrosis, and hypertension. Pannexin-1 has been suggested as an exciting, clinically relevant target in cardiovascular diseases. |
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| AbstractList | Pannexin-1, Pannexin-2, and Pannexin-3 are three members of the Pannexin family of channel-forming glycoprotein. Their primary function is defined by their ability to form single-membrane channels. Pannexin-1 ubiquitously exists in many cells and organs throughout the body and is specially distributed in the circulatory system, while the expressions of Pannexin-2 and Pannexin-3 are mostly restricted to organs and tissues. Pannexin-1 oligomers have been shown to be functional single membrane channels that connect intracellular and extracellular compartments and are not intercellular channels in appositional membranes. The physiological functions of Pannexin-1 are to link to the adenosine triphosphate efflux that acts as a paracrine signal, and regulate cellular inflammasomes in a variety of cell types under physiological and pathophysiological conditions. However, there are still many functions to be explored. This review summarizes recent reports and discusses the role of Pannexin-1 in cardiovascular diseases, including ischemia, arrhythmia, cardiac fibrosis, and hypertension. Pannexin-1 has been suggested as an exciting, clinically relevant target in cardiovascular diseases.Pannexin-1, Pannexin-2, and Pannexin-3 are three members of the Pannexin family of channel-forming glycoprotein. Their primary function is defined by their ability to form single-membrane channels. Pannexin-1 ubiquitously exists in many cells and organs throughout the body and is specially distributed in the circulatory system, while the expressions of Pannexin-2 and Pannexin-3 are mostly restricted to organs and tissues. Pannexin-1 oligomers have been shown to be functional single membrane channels that connect intracellular and extracellular compartments and are not intercellular channels in appositional membranes. The physiological functions of Pannexin-1 are to link to the adenosine triphosphate efflux that acts as a paracrine signal, and regulate cellular inflammasomes in a variety of cell types under physiological and pathophysiological conditions. However, there are still many functions to be explored. This review summarizes recent reports and discusses the role of Pannexin-1 in cardiovascular diseases, including ischemia, arrhythmia, cardiac fibrosis, and hypertension. Pannexin-1 has been suggested as an exciting, clinically relevant target in cardiovascular diseases. Pannexin-1, Pannexin-2, and Pannexin-3 are three members of the Pannexin family of channel-forming glycoprotein. Their primary function is defined by their ability to form single-membrane channels. Pannexin-1 ubiquitously exists in many cells and organs throughout the body and is specially distributed in the circulatory system, while the expressions of Pannexin-2 and Pannexin-3 are mostly restricted to organs and tissues. Pannexin-1 oligomers have been shown to be functional single membrane channels that connect intracellular and extracellular compartments and are not intercellular channels in appositional membranes. The physiological functions of Pannexin-1 are to link to the adenosine triphosphate efflux that acts as a paracrine signal, and regulate cellular inflammasomes in a variety of cell types under physiological and pathophysiological conditions. However, there are still many functions to be explored. This review summarizes recent reports and discusses the role of Pannexin-1 in cardiovascular diseases, including ischemia, arrhythmia, cardiac fibrosis, and hypertension. Pannexin-1 has been suggested as an exciting, clinically relevant target in cardiovascular diseases. |
| Author | Lanfang Li Lu He Di Wu Linxi Chen Zhisheng Jiang |
| AuthorAffiliation | Post-doctoral Mobile Stations for Basic Medicine, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25921414$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neuroscience.2006.03.053 10.1002/cne.21898 10.1093/brain/awq284 10.1016/S0960-9822(00)00576-5 10.1016/j.bbamem.2011.07.031 10.1177/1074248409360356 10.1002/jbmr.509 10.1254/jphs.12202FP 10.1038/bjp.2008.276 10.1523/JNEUROSCI.6062-08.2009 10.1113/jphysiol.2009.180083 10.1113/jphysiol.2014.279299 10.1093/cvr/cvs187 10.1074/jbc.M109.004804 10.1016/j.neuint.2010.12.013 10.1371/journal.pone.0051767 10.1074/jbc.M111.306522 10.1038/emboj.2008.237 10.1007/s12031-011-9646-8 10.1152/ajpcell.00283.2010 10.1016/j.brainres.2011.04.017 10.1152/ajpcell.00122.2010 10.1523/JNEUROSCI.1267-12.2012 10.1016/j.bbamem.2012.01.017 10.1371/journal.pone.0039489 10.1189/jlb.0410211 10.1016/j.bcp.2013.11.007 10.1126/science.1165209 10.1074/jbc.M113.460865 10.1007/s00018-007-7200-1 10.1038/sj.emboj.7601378 10.1074/jbc.M111.276261 10.1007/s11302-007-9078-7 10.1002/jnr.21675 10.1083/jcb.201101050 10.1073/pnas.1018262108 10.1111/j.1471-4159.2004.02947.x 10.1038/nature09413 10.1080/14734220500530082 10.1016/j.bbamem.2011.06.005 10.1074/jbc.M109.004762 10.1074/jbc.M110.115444 10.1007/s00232-012-9453-3 10.1016/j.ejcb.2008.08.004 10.1074/jbc.M110.163477 10.1091/mbc.e09-01-0067 10.1074/jbc.M109.023689 10.1016/j.ygeno.2003.09.025 10.1016/j.neuroscience.2007.01.061 10.1159/000338758 10.1074/jbc.M111.323378 10.1172/JCI200214001 10.1038/nm.2679 10.1182/blood-2010-04-277707 10.1083/jcb.200601115 10.3389/fphys.2014.00096 10.3389/fphys.2014.00063 10.1002/mrd.21280 10.1152/ajpheart.00251.2012 10.1016/j.yjmcc.2012.04.015 10.1242/jcs.056093 10.1074/jbc.M111.260562 10.1165/rcmb.2008-0367OC 10.1371/journal.pone.0040069 10.1074/jbc.M110.130054 10.1074/jbc.M702422200 10.1161/CIRCRESAHA.110.237594 10.1016/j.febslet.2005.12.004 10.1080/15419060802013885 10.1016/j.tcm.2012.06.014 10.1074/jbc.M110.101014 10.1007/s11010-011-0713-9 10.4161/chan.27978 10.1126/scisignal.1160583 10.1152/ajpheart.00305.2011 10.1016/j.febslet.2014.02.004 10.1016/j.abb.2012.03.008 10.1523/JNEUROSCI.0055-10.2010 10.1016/j.febslet.2014.01.031 10.1038/nm.2710 10.1111/j.1474-8673.2009.00435.x 10.1126/science.1126241 10.1152/physrev.00043.2006 10.1242/jcs.009514 10.1016/j.immuni.2007.03.008 10.1111/j.1476-5381.2009.00566.x |
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| Keywords | Pannexin-1 cardiac fibrosis ATP arrhythmia |
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| Notes | Pannexin-1, ATP, arrhythmia, cardiac fibrosis 31-1940/Q Pannexin-1, Pannexin-2, and Pannexin-3 are three members of the Pannexin family of channel-forming glycoprotein. Their primary function is defined by their ability to form single-membrane channels. Pannexin-1 ubiquitously exists in many cells and organs throughout the body and is specially distributed in the circulatory system, while the expressions of Pannexin-2 and Pannexin-3 are mostly restricted to organs and tissues. Pannexin-1 oligomers have been shown to be functional single membrane channels that connect intracellular and extracellular compartments and are not intercellular channels in appositional membranes. The physiological functions of Pannexin-1 are to link to the adenosine triphosphate efflux that acts as a paracrine signal, and regulate cellular inflammasomes in a variety of cell types under physiological and pathophysiological conditions. However, there are still many functions to be explored. This review summarizes recent reports and discusses the role of Pannexin-1 in cardiovascular diseases, including ischemia, arrhythmia, cardiac fibrosis, and hypertension. Pannexin-1 has been suggested as an exciting, clinically relevant target in cardiovascular diseases. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
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| References | Kauffenstein G (null) 2010; 159 Dunn CA (null) 2012; 287 Silverman WR (null) 2009; 284 Schenk U (null) 2008; 1 Prochnow N (null) 2012; 7 Zoidl G (null) 2007; 146 Makarenkova HP (null) 2014; 5 Zhang L (null) 2008; 86 Bond SR (null) 2014; 5 Woehrle T (null) 2010; 116 Penuela S (null) 2013; 1828 Wicki-Stordeur LE (null) 2012; 2012 Thompson RJ (null) 2008; 322 Ambrosi C (null) 2010; 285 Kawamura M (null) 2010; 30 Celetti SJ (null) 2010; 123 Wang XH (null) 2009; 512 Iglesias R (null) 2009; 29 Burnstock G (null) 2009; 29 Sonntag S (null) 2009; 88 Chekeni FB (null) 2010; 467 Shestopalov VI (null) 2008; 65 Bruzzone R (null) 2005; 92 Sorge RE (null) 2012; 18 Iwabuchi S (null) 2011; 58 Nishida M (null) 2008; 27 Velasquez S (null) 2014; 5 Timóteo MA (null) 2014; 87 Wicki-Stordeur LE (null) 2014; 7 Ayna G (null) 2012; 7 Vessey DA (null) 2011; 351 Isakson BE (null) 2014; 8 Looft-Wilson RC (null) 2012; 1818 Retamal MA (null) 2014; 5 Boassa D (null) 2008; 15 Godecke S (null) 2012; 302 Poornima V (null) 2012; 46 Turmel P (null) 2011; 78 Lohman AW (null) 2014; 588 Tanoue A (null) 2002; 109 Lohman AW (null) 2012; 95 Zhan H (null) 2012; 7 Ransford GA (null) 2009; 41 Lamkanfi M (null) 2009; 284 Pinheiro AR (null) 2013; 288 Bunse S (null) 2010; 285 Madry C (null) 2010; 133 Swayne LA (null) 2010; 285 Dolmatova E (null) 2012; 303 Kar R (null) 2012; 524 Lohman AW (null) 2012; 49 Ishikawa M (null) 2011; 193 Dvoriantchikova G (null) 2006; 12 Penuela S (null) 2007; 120 Billaud M (null) 2011; 109 Falk MM (null) 2014; 588 Baranova A (null) 2004; 83 Johnstone SR (null) 2012; 245 Kanneganti TD (null) 2007; 26 Bargiotas P (null) 2011; 108 Jackson WF (null) 2008; 155 Zappala A (null) 2006; 141 Vessey DA (null) 2011; 301 Weilinger NL (null) 2012; 32 Kienitz MC (null) 2011; 286 Pelegrin P (null) 2006; 25 Sumi Y (null) 2010; 299 Gulbransen BD (null) 2012; 18 Murali S (null) 2014; 592 Thompson RJ (null) 2006; 312 Scemes E (null) 2012; 1818 Sandilos JK (null) 2012; 287 Oishi S (null) 2012; 120 Seminario-Vidal L (null) 2009; 284 Cea LA (null) 2014; 5 Woehrle T (null) 2010; 88 Vessey DA (null) 2010; 15 Bao BA (null) 2012; 287 Billaud M (null) 2012; 22 Locovei S (null) 2006; 580 Dando R (null) 2009; 587 Erlinge D (null) 2008; 4 Panchin Y (null) 2000; 10 Ohbuchi T (null) 2011; 1394 Bond SR (null) 2011; 26 Vanden Abeele F (null) 2006; 174 Ray A (null) 2006; 5 Vettel C (null) 2012; 53 Boassa D (null) 2007; 282 Burnstock G (null) 2007; 87 Penuela S (null) 2009; 20 Seminario-Vidal L (null) 2011; 286 |
| References_xml | – volume: 141 start-page: 167 year: 2006 ident: null publication-title: Neuroscience doi: 10.1016/j.neuroscience.2006.03.053 – volume: 512 start-page: 336 year: 2009 ident: null publication-title: J Comp Neurol doi: 10.1002/cne.21898 – volume: 133 start-page: 3755 year: 2010 ident: null publication-title: Brain doi: 10.1093/brain/awq284 – volume: 10 start-page: R473 year: 2000 ident: null publication-title: Curr Biol doi: 10.1016/S0960-9822(00)00576-5 – volume: 1818 start-page: 1895 year: 2012 ident: null publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamem.2011.07.031 – volume: 15 start-page: 190 year: 2010 ident: null publication-title: J Cardiovasc Pharmacol Ther doi: 10.1177/1074248409360356 – volume: 26 start-page: 2911 year: 2011 ident: null publication-title: J Bone Miner Res doi: 10.1002/jbmr.509 – volume: 120 start-page: 296 year: 2012 ident: null publication-title: J Pharmacol Sci doi: 10.1254/jphs.12202FP – volume: 155 start-page: 514 year: 2008 ident: null publication-title: Br J Pharmacol doi: 10.1038/bjp.2008.276 – volume: 29 start-page: 7092 year: 2009 ident: null publication-title: J Neurosci: doi: 10.1523/JNEUROSCI.6062-08.2009 – volume: 587 start-page: 5899 year: 2009 ident: null publication-title: J Physiol doi: 10.1113/jphysiol.2009.180083 – volume: 592 start-page: 4747 year: 2014 ident: null publication-title: J Physiol doi: 10.1113/jphysiol.2014.279299 – volume: 95 start-page: 269 year: 2012 ident: null publication-title: Cardiovasc Res doi: 10.1093/cvr/cvs187 – volume: 284 start-page: 18143 year: 2009 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M109.004804 – volume: 58 start-page: 376 year: 2011 ident: null publication-title: Neurochem Int doi: 10.1016/j.neuint.2010.12.013 – volume: 7 start-page: e51767 year: 2012 ident: null publication-title: PLoS One doi: 10.1371/journal.pone.0051767 – volume: 287 start-page: 8407 year: 2012 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M111.306522 – volume: 27 start-page: 3104 year: 2008 ident: null publication-title: EMBO J doi: 10.1038/emboj.2008.237 – volume: 46 start-page: 585 year: 2012 ident: null publication-title: J Mol Neurosci doi: 10.1007/s12031-011-9646-8 – volume: 302 start-page: C915 year: 2012 ident: null publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00283.2010 – volume: 1394 start-page: 71 year: 2011 ident: null publication-title: Brain Res doi: 10.1016/j.brainres.2011.04.017 – volume: 299 start-page: C1118 year: 2010 ident: null publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00122.2010 – volume: 32 start-page: 12579 year: 2012 ident: null publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1267-12.2012 – volume: 1828 start-page: 15 year: 2013 ident: null publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamem.2012.01.017 – volume: 7 start-page: e39489 year: 2012 ident: null publication-title: PLoS One doi: 10.1371/journal.pone.0039489 – volume: 5 start-page: 58 year: 2014 ident: null publication-title: Front Physiol – volume: 88 start-page: 1181 year: 2010 ident: null publication-title: J Leukoc Biol doi: 10.1189/jlb.0410211 – volume: 87 start-page: 371 year: 2014 ident: null publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2013.11.007 – volume: 322 start-page: 1555 year: 2008 ident: null publication-title: Science doi: 10.1126/science.1165209 – volume: 288 start-page: 27571 year: 2013 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M113.460865 – volume: 65 start-page: 376 year: 2008 ident: null publication-title: Cell Mol Life Sci doi: 10.1007/s00018-007-7200-1 – volume: 25 start-page: 5071 year: 2006 ident: null publication-title: EMBO J doi: 10.1038/sj.emboj.7601378 – volume: 287 start-page: 2600 year: 2012 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M111.276261 – volume: 4 start-page: 1 year: 2008 ident: null publication-title: Purinergic Signal doi: 10.1007/s11302-007-9078-7 – volume: 86 start-page: 2281 year: 2008 ident: null publication-title: J Neurosci Res doi: 10.1002/jnr.21675 – volume: 193 start-page: 1257 year: 2011 ident: null publication-title: J Cell Biol doi: 10.1083/jcb.201101050 – volume: 108 start-page: 20772 year: 2011 ident: null publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1018262108 – volume: 92 start-page: 1033 year: 2005 ident: null publication-title: J Neurochem doi: 10.1111/j.1471-4159.2004.02947.x – volume: 467 start-page: 863 year: 2010 ident: null publication-title: Nature doi: 10.1038/nature09413 – volume: 5 start-page: 189 year: 2006 ident: null publication-title: Cerebellum doi: 10.1080/14734220500530082 – volume: 1818 start-page: 1880 year: 2012 ident: null publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamem.2011.06.005 – volume: 5 start-page: 139 year: 2014 ident: null publication-title: Front Physiol – volume: 5 start-page: 80 year: 2014 ident: null publication-title: Front Physiol – volume: 7 start-page: 287 year: 2014 ident: null publication-title: Front Cell Neurosci – volume: 284 start-page: 20638 year: 2009 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M109.004762 – volume: 285 start-page: 24420 year: 2010 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M110.115444 – volume: 245 start-page: 319 year: 2012 ident: null publication-title: J Membr Biol doi: 10.1007/s00232-012-9453-3 – volume: 88 start-page: 65 year: 2009 ident: null publication-title: Eur J Cell Biol doi: 10.1016/j.ejcb.2008.08.004 – volume: 286 start-page: 290 year: 2011 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M110.163477 – volume: 20 start-page: 4313 year: 2009 ident: null publication-title: Mol Biol Cell doi: 10.1091/mbc.e09-01-0067 – volume: 284 start-page: 20574 year: 2009 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M109.023689 – volume: 83 start-page: 706 year: 2004 ident: null publication-title: Genomics doi: 10.1016/j.ygeno.2003.09.025 – volume: 146 start-page: 9 year: 2007 ident: null publication-title: Neuroscience doi: 10.1016/j.neuroscience.2007.01.061 – volume: 49 start-page: 405 year: 2012 ident: null publication-title: J Vasc Res doi: 10.1159/000338758 – volume: 287 start-page: 11303 year: 2012 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M111.323378 – volume: 109 start-page: 765 year: 2002 ident: null publication-title: J Clin Invest doi: 10.1172/JCI200214001 – volume: 18 start-page: 600 year: 2012 ident: null publication-title: Nat Med doi: 10.1038/nm.2679 – volume: 116 start-page: 3475 year: 2010 ident: null publication-title: Blood doi: 10.1182/blood-2010-04-277707 – volume: 174 start-page: 535 year: 2006 ident: null publication-title: J Cell Biol doi: 10.1083/jcb.200601115 – volume: 5 start-page: 96 year: 2014 ident: null publication-title: Front Physiol doi: 10.3389/fphys.2014.00096 – volume: 5 start-page: 63 year: 2014 ident: null publication-title: Front Physiol doi: 10.3389/fphys.2014.00063 – volume: 78 start-page: 124 year: 2011 ident: null publication-title: Mol Reprod Dev doi: 10.1002/mrd.21280 – volume: 303 start-page: H1208 year: 2012 ident: null publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00251.2012 – volume: 53 start-page: 165 year: 2012 ident: null publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2012.04.015 – volume: 123 start-page: 1363 year: 2010 ident: null publication-title: J Cell Sci doi: 10.1242/jcs.056093 – volume: 286 start-page: 26277 year: 2011 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M111.260562 – volume: 41 start-page: 525 year: 2009 ident: null publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2008-0367OC – volume: 7 start-page: e40069 year: 2012 ident: null publication-title: PLoS One doi: 10.1371/journal.pone.0040069 – volume: 285 start-page: 24977 year: 2010 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M110.130054 – volume: 282 start-page: 31733 year: 2007 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M702422200 – volume: 109 start-page: 80 year: 2011 ident: null publication-title: Circ Res doi: 10.1161/CIRCRESAHA.110.237594 – volume: 580 start-page: 239 year: 2006 ident: null publication-title: FEBS Lett doi: 10.1016/j.febslet.2005.12.004 – volume: 15 start-page: 119 year: 2008 ident: null publication-title: Cell Commun Adhes doi: 10.1080/15419060802013885 – volume: 22 start-page: 68 year: 2012 ident: null publication-title: Trends Cardiovasc Med doi: 10.1016/j.tcm.2012.06.014 – volume: 285 start-page: 38444 year: 2010 ident: null publication-title: J Biol Chem doi: 10.1074/jbc.M110.101014 – volume: 351 start-page: 77 year: 2011 ident: null publication-title: Mol Cell Biochem doi: 10.1007/s11010-011-0713-9 – volume: 2012 start-page: 454180 year: 2012 ident: null publication-title: Stem Cells Int – volume: 8 start-page: 118 year: 2014 ident: null publication-title: Channels doi: 10.4161/chan.27978 – volume: 1 start-page: ra6 year: 2008 ident: null publication-title: Sci Signal doi: 10.1126/scisignal.1160583 – volume: 301 start-page: H881 year: 2011 ident: null publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00305.2011 – volume: 588 start-page: 1379 year: 2014 ident: null publication-title: FEBS Lett doi: 10.1016/j.febslet.2014.02.004 – volume: 524 start-page: 2 year: 2012 ident: null publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2012.03.008 – volume: 30 start-page: 3886 year: 2010 ident: null publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0055-10.2010 – volume: 588 start-page: 1221 year: 2014 ident: null publication-title: FEBS Lett doi: 10.1016/j.febslet.2014.01.031 – volume: 12 start-page: 1417 year: 2006 ident: null publication-title: Mol Vis – volume: 18 start-page: 595 year: 2012 ident: null publication-title: Nat Med doi: 10.1038/nm.2710 – volume: 29 start-page: 63 year: 2009 ident: null publication-title: Auton Autacoid Pharmacol doi: 10.1111/j.1474-8673.2009.00435.x – volume: 312 start-page: 924 year: 2006 ident: null publication-title: Science doi: 10.1126/science.1126241 – volume: 87 start-page: 659 year: 2007 ident: null publication-title: Physiol Rev doi: 10.1152/physrev.00043.2006 – volume: 120 start-page: 3772 year: 2007 ident: null publication-title: J Cell Sci doi: 10.1242/jcs.009514 – volume: 26 start-page: 433 year: 2007 ident: null publication-title: Immunity doi: 10.1016/j.immuni.2007.03.008 – volume: 159 start-page: 576 year: 2010 ident: null publication-title: Br J Pharmacol doi: 10.1111/j.1476-5381.2009.00566.x |
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| SubjectTerms | Cardiovascular Diseases - physiopathology Humans Nerve Tissue Proteins - physiology 三磷酸腺苷 循环系统 心肌纤维化 心血管疾病 渠道 生理功能 细胞外 膜通道 |
| Title | Pannexin-1 channels and their emerging functions in cardiovascular diseases |
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