Activation of Heme Oxygenase-1 is Involved in the Preventive Effect of Honokiol against Oxidative Damage in Human Retinal Pigment Epithelial Cells

• Published in: Biotechnology and bioprocess engineering Vol. 27; no. 6; pp. 975 - 986
• Main Authors: Hong, Su Hyun, Park, Cheol, Hwangbo, Hyun, Bang, EunJin, Kim, Sung Ok, Shim, Jung-Hyun, Park, Shin-Hyung, Lee, Hyesook, Leem, Sun-Hee, Kim, Gi-Young, Choi, Yung Hyun
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.12.2022; Springer Nature B.V
• Subjects: antioxidant activity; Antioxidants; Apoptosis; Bcl-2 protein; Bioactive compounds; Biocompatibility; Biotechnology; Cell cycle; cell cycle checkpoints; Cell viability; Chemistry; Chemistry and Materials Science; Chronic illnesses; Cytochrome c; Cytochromes; Cytoplasm; Cytotoxicity; Damage; DNA damage; Epithelium; Heme; heme oxygenase (biliverdin-producing); Heme oxygenase (decyclizing); honokiol; humans; Hydrogen peroxide; Industrial and Production Engineering; Magnolia; Membrane potential; Mitochondria; mitochondrial membrane; Myoblasts; Oxidative stress; Oxygenase; Phosphorylation; Protoporphyrin; Reactive oxygen species; Research Paper; Retina; Retinal pigment epithelium; Toxicity; zinc; retinal pigment epithelial cells; honokiol; reactive oxygen species; Nrf2/HO-1

Previous studies have shown that honokiol, a bioactive compound originated from the Magnolia , has beneficial effects on various chronic diseases. Although our previous study has demonstrated that honokiol effectively protects C2C12 myoblasts against hydrogen peroxide (H 2 O 2 )-induced oxidative st...