Aldosterone-synthase overexpression in heart: a tool to explore aldosterone’s effects
Clinical observations indicate that elevated aldosterone impairs cardiovascular function. The mechanisms, however, are not totally understood although total and cardiovascular mortality are decreased by aldosterone antagonists. Experimentally, increased plasma aldosterone induces pericoronary inflam...
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| Published in | Molecular and cellular endocrinology Vol. 217; no. 1; pp. 213 - 219 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier Ireland Ltd
31.03.2004
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| Abstract | Clinical observations indicate that elevated aldosterone impairs cardiovascular function. The mechanisms, however, are not totally understood although total and cardiovascular mortality are decreased by aldosterone antagonists. Experimentally, increased plasma aldosterone induces pericoronary inflammation and cardiac fibrosis. Our laboratory has discovered that aldosterone is synthesized in the rat heart, and has demonstrated that this cardiac aldosterone is involved in post-infarction cardiac remodeling. In man, activated cardiac aldosterone production has been described in patients with heart failure. In transgenic mice that overexpress aldosterone-synthase in the heart, we observe a normal cardiac function but a major coronary dysfunction, more pronounced in males. These observations converge to a potential physiological and pathological relevance of this system. Beneficial effects of anti-aldosterone treatment in heart failure may thus be secondary in part to blockade of cardiac aldosterone action. |
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| AbstractList | Clinical observations indicate that elevated aldosterone impairs cardiovascular function. The mechanisms, however, are not totally understood although total and cardiovascular mortality are decreased by aldosterone antagonists. Experimentally, increased plasma aldosterone induces pericoronary inflammation and cardiac fibrosis. Our laboratory has discovered that aldosterone is synthesized in the rat heart, and has demonstrated that this cardiac aldosterone is involved in post-infarction cardiac remodeling. In man, activated cardiac aldosterone production has been described in patients with heart failure. In transgenic mice that overexpress aldosterone-synthase in the heart, we observe a normal cardiac function but a major coronary dysfunction, more pronounced in males. These observations converge to a potential physiological and pathological relevance of this system. Beneficial effects of anti-aldosterone treatment in heart failure may thus be secondary in part to blockade of cardiac aldosterone action. |
| Author | Bendall, J.K Robidel, E Delcayre, C Milliez, P Fuchs, S Ambroisine, M.L Nehme, J Heymes, C Garnier, A Swynghedauw, B |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15134820$$D View this record in MEDLINE/PubMed |
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| Keywords | Heart failure Cardiac hormones Coronary dysfunction Aldosterone Transgenic mice |
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| Snippet | Clinical observations indicate that elevated aldosterone impairs cardiovascular function. The mechanisms, however, are not totally understood although total... |
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| SubjectTerms | Aldosterone Aldosterone - metabolism Animals Cardiac hormones Coronary Disease - genetics Coronary Disease - physiopathology Coronary dysfunction Cytochrome P-450 CYP11B2 - genetics Cytochrome P-450 CYP11B2 - metabolism Female Gene Expression Regulation - genetics Gene Expression Regulation - physiology Heart failure Heart Failure - drug therapy Heart Failure - physiopathology Humans Male Mice Mice, Transgenic Mineralocorticoid Receptor Antagonists - therapeutic use Myocardium - metabolism Myocardium - pathology Rats Sex Factors Transgenic mice Ventricular Remodeling - physiology |
| Title | Aldosterone-synthase overexpression in heart: a tool to explore aldosterone’s effects |
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