Cryptococcal Choroid Plexitis and Non-Communicating Hydrocephalus
Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation...
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Published in | Curēus (Palo Alto, CA) Vol. 12; no. 6 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Palo Alto
Cureus Inc
08.06.2020
Cureus |
Subjects | |
Online Access | Get full text |
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Abstract | Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation of Cryptococcus infection. In cases in which choroid plexus involvement blocks cerebrospinal fluid flow, obstructive hydrocephalus may occur. Here we report the case of a 63-year-old woman who presented with choroid plexitis causing obstructive hydrocephalus at the foramen of Monro. Endoscopic biopsy confirmed Cryptococcus neoformans, and the patient was successfully treated with amphotericin, flucytosine, and fluconazole. With proper recognition and treatment of this pathology, patients can fully recover from this condition. |
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AbstractList | Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation of Cryptococcus infection. In cases in which choroid plexus involvement blocks cerebrospinal fluid flow, obstructive hydrocephalus may occur. Here we report the case of a 63-year-old woman who presented with choroid plexitis causing obstructive hydrocephalus at the foramen of Monro. Endoscopic biopsy confirmed Cryptococcus neoformans, and the patient was successfully treated with amphotericin, flucytosine, and fluconazole. With proper recognition and treatment of this pathology, patients can fully recover from this condition. Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation of Cryptococcus infection. In cases in which choroid plexus involvement blocks cerebrospinal fluid flow, obstructive hydrocephalus may occur. Here we report the case of a 63-year-old woman who presented with choroid plexitis causing obstructive hydrocephalus at the foramen of Monro. Endoscopic biopsy confirmed Cryptococcus neoformans, and the patient was successfully treated with amphotericin, flucytosine, and fluconazole. With proper recognition and treatment of this pathology, patients can fully recover from this condition. |
Author | O'Connor, Kyle P Bohnstedt, Bradley Pelargos, Panayiotis E Milton, Camille K Peterson, Jo Elle G |
AuthorAffiliation | 1 Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, USA 3 Neurosurgery, Indiana University, Indianapolis, USA 2 Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA |
AuthorAffiliation_xml | – name: 3 Neurosurgery, Indiana University, Indianapolis, USA – name: 2 Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA – name: 1 Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, USA |
Author_xml | – sequence: 1 givenname: Kyle P surname: O'Connor fullname: O'Connor, Kyle P – sequence: 2 givenname: Panayiotis E surname: Pelargos fullname: Pelargos, Panayiotis E – sequence: 3 givenname: Camille K surname: Milton fullname: Milton, Camille K – sequence: 4 givenname: Jo Elle G surname: Peterson fullname: Peterson, Jo Elle G – sequence: 5 givenname: Bradley surname: Bohnstedt fullname: Bohnstedt, Bradley |
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Copyright | Copyright © 2020, O'Connor et al. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2020, O'Connor et al. 2020 O'Connor et al. |
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Snippet | Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid... Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid... |
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SubjectTerms | Antifungal agents Antigens Biopsy Case reports Encephalitis Endoscopy Fungal infections Health sciences Hydrocephalus Infections Infectious Disease Magnetic resonance imaging Meningitis Neurology Neurosurgery Pathology Patients Serology Tuberculosis |
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Title | Cryptococcal Choroid Plexitis and Non-Communicating Hydrocephalus |
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