Cryptococcal Choroid Plexitis and Non-Communicating Hydrocephalus

Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation...

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Published inCurēus (Palo Alto, CA) Vol. 12; no. 6
Main Authors O'Connor, Kyle P, Pelargos, Panayiotis E, Milton, Camille K, Peterson, Jo Elle G, Bohnstedt, Bradley
Format Journal Article
LanguageEnglish
Published Palo Alto Cureus Inc 08.06.2020
Cureus
Subjects
Antifungal agents
Antigens
Biopsy
Case reports
Encephalitis
Endoscopy
Fungal infections
Health sciences
Hydrocephalus
Infections
Infectious Disease
Magnetic resonance imaging
Meningitis
Neurology
Neurosurgery
Pathology
Patients
Serology
Tuberculosis
United States > US
Oklahoma
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Abstract Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation of Cryptococcus infection. In cases in which choroid plexus involvement blocks cerebrospinal fluid flow, obstructive hydrocephalus may occur. Here we report the case of a 63-year-old woman who presented with choroid plexitis causing obstructive hydrocephalus at the foramen of Monro. Endoscopic biopsy confirmed Cryptococcus neoformans, and the patient was successfully treated with amphotericin, flucytosine, and fluconazole. With proper recognition and treatment of this pathology, patients can fully recover from this condition.
AbstractList Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation of Cryptococcus infection. In cases in which choroid plexus involvement blocks cerebrospinal fluid flow, obstructive hydrocephalus may occur. Here we report the case of a 63-year-old woman who presented with choroid plexitis causing obstructive hydrocephalus at the foramen of Monro. Endoscopic biopsy confirmed Cryptococcus neoformans, and the patient was successfully treated with amphotericin, flucytosine, and fluconazole. With proper recognition and treatment of this pathology, patients can fully recover from this condition.
Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid barrier, serves as one potential entry point for the pathogen, disease involvement of the choroid plexus itself remains a very rare manifestation of Cryptococcus infection. In cases in which choroid plexus involvement blocks cerebrospinal fluid flow, obstructive hydrocephalus may occur. Here we report the case of a 63-year-old woman who presented with choroid plexitis causing obstructive hydrocephalus at the foramen of Monro. Endoscopic biopsy confirmed Cryptococcus neoformans, and the patient was successfully treated with amphotericin, flucytosine, and fluconazole. With proper recognition and treatment of this pathology, patients can fully recover from this condition.
Author O'Connor, Kyle P
Bohnstedt, Bradley
Pelargos, Panayiotis E
Milton, Camille K
Peterson, Jo Elle G
AuthorAffiliation 1 Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, USA
3 Neurosurgery, Indiana University, Indianapolis, USA
2 Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
AuthorAffiliation_xml – name: 3 Neurosurgery, Indiana University, Indianapolis, USA
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crossref_primary_10_7759_cureus_18975
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Copyright Copyright © 2020, O'Connor et al. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © 2020, O'Connor et al. 2020 O'Connor et al.
Copyright_xml – notice: Copyright © 2020, O'Connor et al. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright © 2020, O'Connor et al. 2020 O'Connor et al.
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Snippet Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid...
Cryptococcus neoformans is a fungus that commonly invades the central nervous system. While the choroid plexus, the site of the blood-cerebrospinal fluid...
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SubjectTerms Antifungal agents
Antigens
Biopsy
Case reports
Encephalitis
Endoscopy
Fungal infections
Health sciences
Hydrocephalus
Infections
Infectious Disease
Magnetic resonance imaging
Meningitis
Neurology
Neurosurgery
Pathology
Patients
Serology
Tuberculosis
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Title Cryptococcal Choroid Plexitis and Non-Communicating Hydrocephalus
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