HIV-infected progressors and long-term non-progressors differ in their capacity to respond to an A-class CpG oligodeoxynucleotide
We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative...
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| Published in | AIDS (London) Vol. 19; no. 16; pp. 1924 - 1925 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
Lippincott Williams & Wilkins
04.11.2005
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0269-9370 |
| DOI | 10.1097/01.aids.0000191229.52385.5f |
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| Abstract | We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts. |
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| AbstractList | We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts.We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts. We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts. |
| Author | Iribarren, José Antonio Saez, Raquel Echaniz, Pilar Cuadrado, Emilio de Juan, Maria Dolores |
| Author_xml | – sequence: 1 givenname: Raquel surname: Saez fullname: Saez, Raquel – sequence: 2 givenname: Pilar surname: Echaniz fullname: Echaniz, Pilar – sequence: 3 givenname: Maria Dolores surname: de Juan fullname: de Juan, Maria Dolores – sequence: 4 givenname: José Antonio surname: Iribarren fullname: Iribarren, José Antonio – sequence: 5 givenname: Emilio surname: Cuadrado fullname: Cuadrado, Emilio |
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| CitedBy_id | crossref_primary_10_1111_j_1365_2567_2007_02530_x crossref_primary_10_1007_s12026_016_8862_2 crossref_primary_10_1016_j_imlet_2007_01_006 crossref_primary_10_1016_S1473_3099_06_70656_9 crossref_primary_10_1038_nrd2059 crossref_primary_10_1002_eji_200635901 crossref_primary_10_2165_00063030_200721060_00006 |
| Cites_doi | 10.1002/eji.200324032 10.4049/jimmunol.172.8.4779 10.1038/ng934 10.4049/jimmunol.171.5.2538 10.4049/jimmunol.168.11.5764 10.4049/jimmunol.171.8.4320 10.1182/blood.V98.4.906 10.1016/S0264-410X(02)00202-5 10.4049/jimmunol.166.4.2372 10.1016/S1471-4906(01)01925-1 10.4049/jimmunol.171.11.5663 10.4049/jimmunol.173.8.5305 10.1073/pnas.0403744101 |
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| Keywords | Infection Immunopathology Viral disease AIDS Asymptomatic Immune deficiency Long term |
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| References | Alter (R14-27-20210130) 2004; 173 Levy (R1-27-20210130) 2001; 22 Lore (R9-27-20210130) 2003; 171 Verthelyi (R10-27-20210130) 2001; 166 Soumelis (R4-27-20210130) 2001; 98 Scott-Algara (R2-27-20210130) 2003; 171 Azzoni (R15-27-20210130) 2002; 168 Vollmer (R5-27-20210130) 2004; 34 Sivori (R11-27-20210130) 2004; 101 Tritel (R8-27-20210130) 2003; 171 Pan (R12-27-20210130) 2004; 172 Ayash-Rashkovsky (R7-27-20210130) 2002; 20 Martin (R13-27-20210130) 2002; 31 |
| References_xml | – volume: 34 start-page: 251 year: 2004 ident: R5-27-20210130 article-title: Characterization of three CpG oligodeoxynucleotide classes with distinct immunstimulatory activities publication-title: Eur J Immunol doi: 10.1002/eji.200324032 – volume: 172 start-page: 4779 year: 2004 ident: R12-27-20210130 article-title: Regulation of dendritic cell function by NK cells: mechanism underlying the synergism in the combination therapy of IL-12 and 4-1BB activation publication-title: J Immunol doi: 10.4049/jimmunol.172.8.4779 – volume: 31 start-page: 429 year: 2002 ident: R13-27-20210130 article-title: Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS publication-title: Nat Genet doi: 10.1038/ng934 – volume: 171 start-page: 2538 year: 2003 ident: R8-27-20210130 article-title: Prime-boost vaccination with HIV-1 gag protein and CpG oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune response publication-title: J Immunol doi: 10.4049/jimmunol.171.5.2538 – volume: 168 start-page: 5764 year: 2002 ident: R15-27-20210130 article-title: Sustained impairment of IFNγ secretion in suppressed HIV-infected patients despite mature NK recovery: evidence for a defective reconstitution of innate immunity publication-title: J Immunol doi: 10.4049/jimmunol.168.11.5764 – volume: 171 start-page: 4320 year: 2003 ident: R9-27-20210130 article-title: Toll like receptors ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses publication-title: J Immunol doi: 10.4049/jimmunol.171.8.4320 – volume: 98 start-page: 906 year: 2001 ident: R4-27-20210130 article-title: Depletion of circulating natural type interferon-producing cells in HIV-infected AIDS patients publication-title: Blood doi: 10.1182/blood.V98.4.906 – volume: 20 start-page: 2684 year: 2002 ident: R7-27-20210130 article-title: Generation of TH1 immune responses to inactivated, gp120-depleted HIV-1 in mice with a dominant Th2 biased immune profile via immunostimulatory oligonucleotides – relevance to AIDS vaccines in developing countries publication-title: Vaccine doi: 10.1016/S0264-410X(02)00202-5 – volume: 166 start-page: 2372 year: 2001 ident: R10-27-20210130 article-title: Human peripheral blood cells differentially recognize and respond to two distnct CpG motifs publication-title: J Immunol doi: 10.4049/jimmunol.166.4.2372 – volume: 22 start-page: 312 year: 2001 ident: R1-27-20210130 article-title: The importance of the innate immune system in controlling HIV infection and disease publication-title: Trends Immunol doi: 10.1016/S1471-4906(01)01925-1 – volume: 171 start-page: 5663 year: 2003 ident: R2-27-20210130 article-title: Increased NK cell activity in HIV-1 exposed but uninfected vietnamese intravascular drug users publication-title: J Immunol doi: 10.4049/jimmunol.171.11.5663 – volume: 173 start-page: 5305 year: 2004 ident: R14-27-20210130 article-title: Increased natural killer cell activity in viremic HIV-1 infection publication-title: J Immunol doi: 10.4049/jimmunol.173.8.5305 – volume: 101 start-page: 10116 year: 2004 ident: R11-27-20210130 article-title: CpG and double stranded RNA trigger human NK cells by toll like receptors: induction for cytokine release and cytotoxicity against tumors and dendritic cells publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0403744101 |
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| SubjectTerms | Biological and medical sciences Case-Control Studies Disease Progression Follow-Up Studies HIV Infections - immunology Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Interferon-gamma - biosynthesis Killer Cells, Natural - metabolism Medical sciences Oligodeoxyribonucleotides - pharmacology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| Title | HIV-infected progressors and long-term non-progressors differ in their capacity to respond to an A-class CpG oligodeoxynucleotide |
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