Synthesis of 15P-Conjugated PPy-modified Gold Nanoparticles and Their Application to Photothermal Therapy of Ovarian Cancer

• Published in: Chemical research in Chinese universities Vol. 30; no. 6; pp. 959 - 964
• Main Authors: Wang, Li, Wang, Liping, Xu, Tianshu, Guo, Changrun, Liu, Chuanzhi, Zhang, Hao, Li, Jing, Liang, Zhiqing
• Format: Journal Article
• Language: English
• Published: Heidelberg Jilin University and The Editorial Department of Chemical Research in Chinese Universities 01.12.2014; The 208 Hospital of PLA, Changchun 130062, P.R.China%College of Life Science, Jilin University, Changchun 130012, P.R.China%College of Life Science, Changchun University of Science and Technology, Changchun 130012, P.R.China%State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, P.R.China; Department of Obstetrics & Gynecology, Southwest Hospital, the Third Military Medical University, Chongqing 400038, P.R.China
• Subjects: Analytical Chemistry; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Inorganic Chemistry; Organic Chemistry; Physical Chemistry; 修饰; 光热; 卵巢癌; 合成; 应用; 聚吡咯; 金纳米粒子; 靶向治疗; Photothermal therapy; Gold nanorod; SK-OV-3 cell; Tumor cell
• ISSN: 1005-9040; 2210-3171
• DOI: 10.1007/s40242-014-4039-5

In this work, we synthesized the polypyrrole（PPy） modified gold nanoparticles and demonstrated their negligible cytotoxicity in vitro. These nanoparticles have also been demonstrated to efficiently ablate different kinds of tumor cells in vitro under the irradiation of the near-infrared laser. When the PPy modified gold nanoparticles were conjugated with the tumor-targeted molecule of 15P（sequence： SHSWHWLPNLRHYAS）, these conjugates displayed hyperthermia effects on the human ovarian cancer cell line SK-OV-3 cells in vitro under the irradiation of near-infrared laser, showing great tumor-targeted treatment efficiency. To determine the potential hyperthermia effect of PPy modified gold nanoparticles or 15P-conjugate on tumor cells in vivo, the SK-OV-3 cells were used to induce the subcutaneous tumor-bearing nude mice. The significant inhibition effects of near-infrared laser mediated PPy modified gold nanoparticles or 15P-conjugate on the tumor growth were observed. These composite results suggest that the 15P-conjugated PPy modified gold nanoparticles exhibit great biocompatibility, particularly tumor-targeted effect and the effective photothermal ablation of tumor cells, which warrants the potential therapeutic value of this conjugate for further application to the in vivo localized tumor therapy.