Pharmacokinetics of Cenobamate: Results From Single and Multiple Oral Ascending‐Dose Studies in Healthy Subjects

• Published in: Clinical pharmacology in drug development Vol. 9; no. 4; pp. 428 - 443
• Main Authors: Vernillet, Laurent, Greene, Stephen A., Kamin, Marc
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2020
• Subjects: antiepileptic drug; cenobamate; Drug dosages; Epilepsy; pharmacokinetic; Pharmacokinetics; Pharmacology; safety; YKP3089; epilepsy; YKP3089; antiepileptic drug; pharmacokinetic; safety; cenobamate

Cenobamate (YKP3089) is an antiepileptic drug recently approved by the Food and Drug Administration for the treatment of focal (partial‐onset) seizures in adults. The objectives of a first‐in‐human single‐ascending‐dose study and 3 multiple‐ascending‐dose studies were to characterize the pharmacokin...