Chemoresistance in acute myeloid leukemia: An alternative single‐cell RNA sequencing approach

• Published in: Hematological oncology Vol. 41; no. 3; pp. 499 - 509
• Main Authors: Cheng, Po‐Liang, Hsiao, Tzu‐Hung, Chen, Chung‐Hsing, Hung, Miao‐Neng, Jhan, Pei‐Pei, Lee, Li‐Wen, Wu, Ting‐Shuan, Tsai, Jia‐Rung, Teng, Chieh‐Lin Jerry
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2023
• Subjects: Acute myeloid leukemia; Biomarkers; CD9 antigen; Cell differentiation; Chemoresistance; Gene sequencing; Genetic markers; Hematopoiesis; Hematopoietic stem cells; Hemopoiesis; Leukemia; leukemia stem cells; Myc protein; Oxidative phosphorylation; Phosphorylation; Progenitor cells; Remission; Ribonucleic acid; RNA; single‐cell RNA‐seq; Stem cells; TOR protein; single-cell RNA-seq; chemoresistance; leukemia stem cells; acute myeloid leukemia

Our previous study demonstrated that myc, mitochondrial oxidative phosphorylation, mTOR, and stemness are independently responsible for chemoresistance in acute myeloid leukemia (AML) cells. This study aimed to identify potential mechanisms of chemoresistance of the “7 + 3” induction in AML by using...