lncRNA CERS6‐AS1 as ceRNA promote cell proliferation of breast cancer by sponging miR‐125a‐5p to upregulate BAP1 expression

• Published in: Molecular carcinogenesis Vol. 59; no. 10; pp. 1199 - 1208
• Main Authors: Yan, Liang, Li, Kai, Feng, Zunyong, Zhang, Yizongheng, Han, Renrui, Ma, Jinzhu, Zhang, Jieling, Wu, Xu, Liu, Haijun, Jiang, Yuxin, Zhang, Yao, Zhu, Yiping
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2020
• Subjects: Animals; Apoptosis; Bioinformatics; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell growth; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; lncRNA CERS6‐AS1; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - genetics; Mice; Mice, Nude; MicroRNAs - genetics; miRNA; miR‐125a‐5p; Oligonucleotides, Antisense - genetics; Polymerase chain reaction; RNA, Long Noncoding - genetics; Sphingosine N-Acyltransferase - antagonists & inhibitors; Sphingosine N-Acyltransferase - genetics; Tumor Cells, Cultured; Tumor suppressor genes; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Ubiquitin Thiolesterase - genetics; Ubiquitin Thiolesterase - metabolism; Xenograft Model Antitumor Assays; breast cancer; lncRNA CERS6-AS1; miR-125a-5p

Long noncoding RNAs (lncRNAs) can act as oncogene and tumor suppressor genes in many types of cancers including breast cancer (BC). Our previous study has indicated microRNA (miR)‐125a‐5p was downregulated and function as a tumor suppressor in BC. However, its upstream regulation mechanism is still...