Targeted β‐catenin ubiquitination and degradation by multifunctional stapled peptides

• Published in: Journal of peptide science Vol. 28; no. 7; pp. e3389 - n/a
• Main Authors: Wang, Xiaofeng, Dong, Liuli, Cheng, Jiongjia, Verdine, Gregory L., Lin, Aijun, Chu, Qian
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2022
• Subjects: beta Catenin - genetics; beta Catenin - metabolism; Cancer; Catenin; Colorectal carcinoma; Degradation; Drug development; Gene expression; Humans; MDM2 protein; multifunctional stapled peptide; p53 Protein; Peptides; Peptides - metabolism; Proteasomes; Proteins; Signal transduction; Signaling; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Ubiquitins - genetics; Ubiquitins - metabolism; Wnt protein; Wnt Signaling Pathway; β‐catenin; β-catenin; degradation; multifunctional stapled peptide; Wnt signaling pathway; ubiquitination

Aberrant activation of the Wnt signaling pathway has been identified in numerous types of cancer. One common feature of oncogenic Wnt regulation involves an increase in the cellular levels of β‐catenin due to interference with its constitutive ubiquitin‐dependent degradation. Targeting β‐catenin has...