Hepatocellular Mitochondrial Alterations in Patients With Chronic Hepatitis C: Ultrastructural and Biochemical Findings

• Published in: The American journal of gastroenterology Vol. 94; no. 8; pp. 2198 - 2205
• Main Authors: Barbaro, Giuseppe, Di Lorenzo, Gabriella, Asti, Annalia, Ribersani, Michela, Belloni, Giancarlo, Grisorio, Benvenuto, Filice, Gaetano, Barbarini, Giorgio
• Format: Journal Article
• Language: English
• Published: Oxford . 01.08.1999; Blackwell Publishing
• Subjects: Adult; Biological and medical sciences; Biopsy; DNA, Mitochondrial - ultrastructure; Female; Genotype; Glutathione - blood; Hepacivirus - genetics; Hepatitis C virus; Hepatitis C, Chronic - pathology; Human viral diseases; Humans; Infectious diseases; Lipid Peroxidation - physiology; Liver - pathology; Liver Function Tests; Male; Malondialdehyde - blood; Medical sciences; Microscopy, Electron; Middle Aged; Mitochondria, Liver - ultrastructure; Oxidation-Reduction; Viral diseases; Viral hepatitis; Human; Biochemical analysis; Pathogenesis; Hepatic disease; Genotype; Electron microscopy; Infection; Virus; Polymerase chain reaction; Pathology; Mitochondria; Hepatocyte; Oxidative phosphorylation; Viral disease; Digestive diseases; Molecular biology; Flaviviridae; Hepatitis C virus; Hepacivirus; Glutathione; Viral hepatitis C

Hepatitis C virus (HCV) infection is associated with increased lipoperoxidation, which may lead to interference with mitochondrial function with possible depletion of mitochondrial DNA (mtDNA). We correlated the ultrastructural findings of liver biopsy specimens with the lipoperoxidation markers and...