LATS‐regulated nuclear‐cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial–mesenchymal transition

• Published in: Molecular carcinogenesis Vol. 62; no. 7; pp. 963 - 974
• Main Authors: Zhang, Feng, Gao, Jie, Liu, Xudong, Sun, Yaohui, Liu, Long, Hu, Bowen, Wang, Zhihui, Shi, Jihua, Guo, Wenzhi, Zhang, Shuijun
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2023
• Subjects: Cell migration; Cholesterol; Gene expression; HCC; Hepatocellular carcinoma; Hepatoma; Kinases; LATS; Liver cancer; Medical prognosis; Metastases; Microvasculature; Nuclear transport; nuclear‐cytoplasmic translocation; SREBP2; Therapeutic targets; Tumor suppressor genes; Tumors; SREBP2; nuclear-cytoplasmic translocation; HCC; LATS

Abnormal cholesterol synthesis plays a crucial role in the development of hepatocellular carcinoma (HCC). Sterol regulatory element‐binding protein 2 (SREBP2) is involved in cholesterol synthesis by translocating to the nucleus where it stimulates the transcription of genes encoding enzymes involved...