Targeting NF‐κB/COX‐2 signaling by soyasaponin I alleviates diclofenac‐induced gastric ulceration in male albino rats

• Published in: Cell biochemistry and function Vol. 42; no. 1; pp. e3927 - n/a
• Main Authors: Morsi, Ahmed A., Shawky, Lamiaa M., Shawky, Tamer M., Bahr, Mohamed H., Alnasr, Mahmoud Tawfiq Abu, El Bana, Eman
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2024
• Subjects: Animal models; Animals; Biochemical analysis; Biochemistry; Cyclooxygenase 2; Diclofenac; Dinoprostone; Down-regulation; Eosine Yellowish-(YS); Gene expression; Immunohistochemistry; Inflammation; Ki-67 Antigen; Male; Males; Mucosa; Natural resources; NF-kappa B; Nonsteroidal anti-inflammatory drugs; Oleanolic Acid - analogs & derivatives; oxidative stress; Phenylenediamines; phytochemicals; Polymerase chain reaction; Prostaglandin E2; Prostaglandin endoperoxide synthase; Ranitidine; rat stomach; Rats; Rats, Wistar; Saponins; Soyasaponin; Staining; Stomach Ulcer - chemically induced; Stomach Ulcer - drug therapy; Surface defects; Ulcer; Ulcers; phytochemicals; immunohistochemistry; inflammation; rat stomach; oxidative stress

Gastric ulceration is a prevalent worldwide clinical presentation due to altered gastric defense mechanisms. Nonsteroidal anti‐inflammatory drugs are one of the common causes of gastric ulcers mediated by the release of inflammatory mediators. The study aimed to investigate the potential protective...