The relationship between matrix metalloproteinases (MMP-3, -8, -9) in serum and peripheral lymphocytes (CD8+, CD56+) in Down syndrome children with gingivitis

• Published in: Journal of periodontal research Vol. 49; no. 6; pp. 742 - 750
• Main Authors: Tsilingaridis, G., Yucel-Lindberg, T., Concha Quezada, H., Modéer, T.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.12.2014
• Subjects: Adolescent; CD56 Antigen - analysis; CD8 Antigens - analysis; CD8-Positive T-Lymphocytes - immunology; Child; crevicular fluid; Cross-Sectional Studies; Down syndrome; Down Syndrome - blood; Down Syndrome - enzymology; Down Syndrome - immunology; Female; Gingival Crevicular Fluid - enzymology; Gingival Crevicular Fluid - immunology; Gingivitis - blood; Gingivitis - enzymology; Gingivitis - immunology; Humans; Killer Cells, Natural - immunology; Lipopolysaccharides - pharmacology; Male; Matrix Metalloproteinase 3 - blood; Matrix Metalloproteinase 8 - blood; Matrix Metalloproteinase 9 - blood; matrix metalloproteinases; Pilot Projects; Porphyromonas gingivalis; serum; T cells; Tissue Inhibitor of Metalloproteinase-1 - blood; Tissue Inhibitor of Metalloproteinase-2 - blood; Tissue Inhibitor of Metalloproteinase-3 - blood; Young Adult; crevicular fluid; Down syndrome; T cells; serum; matrix metalloproteinases

Background and Objective Altered immune response may be a major contributor to periodontal disease in Down syndrome. This study investigated the relationship between peripheral lymphocytes and matrix metalloproteinases (MMPs) in serum in Down syndrome children with gingivitis. Material and Methods C...