In vitro–in vivo extrapolation of bexarotene metabolism in the presence of chronic kidney disease and acute kidney injury in rat using physiologically based pharmacokinetic modeling and extrapolation to human - Alsmadi, Mo'tasem M.; Alzughoul, Saja B. (Biopharmaceutics & drug disposition, 2023)
Keywords: acute kidney injury; Acute Kidney Injury - metabolism; Animals; Bexarotene; bexarotene metabolism; Blood Proteins - metabolism; chronic kidney disease; Humans; Kidney diseases; Liver - metabolism; Lymphoma; Metabolism; Pharmaceutical Preparations - metabolism; Pharmacokinetics; physiologically based pharmacokinetics; Plasma; Protein turnover; Rats; Renal function; Renal Insufficiency, Chronic - metabolism; United States; uremic toxins; United States; bexarotene metabolism; chronic kidney disease; acute kidney injury; uremic toxins; physiologically based pharmacokinetics