Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives

• Published in: Journal of applied toxicology Vol. 41; no. 10; pp. 1687 - 1699
• Main Authors: Canavez, Andrezza Di Pietro Micali, Oliveira Prado Corrêa, Gabriela, Isaac, Vera Lucia Borges, Schuck, Desiree Cigaran, Lorencini, Marcio
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.10.2021
• Subjects: Benzalkonium chloride; Benzoic acid; Benzyl alcohol; Carcinogenicity; Carcinogens; Consumer Product Safety; cosmetic preservatives; Cosmetics; Cosmetics - chemistry; Cosmetics - toxicity; Decision trees; Dermal absorption; Dermatitis - diagnosis; Dermatitis, Phototoxic - diagnosis; Exposure; exposure assessment; Eye Diseases - diagnosis; Genotoxicity; Hazard assessment; Health risks; Humans; Ingredients; Irritation; Mutagenicity; Phenoxyethanol; Phototoxicity; Potassium; Potassium sorbate; Preservatives; Preservatives, Pharmaceutical - chemistry; Preservatives, Pharmaceutical - toxicity; Product safety; Risk assessment; Risk Assessment - methods; risk characterization; Risk levels; Safety; safety evaluation; Skin; Sodium; Sodium benzoate; Toxicity; Toxicity Tests - methods; hazard assessment; risk characterization; cosmetic preservatives; exposure assessment; safety evaluation

The safety assessment of cosmetic products is based on the safety of the ingredients, which requires information on chemical structures, toxicological profiles, and exposure data. Approximately 6% of the population is sensitized to cosmetic ingredients, especially preservatives and fragrances. In th...