Silibinin affects the pharmacokinetics of methadone in rats

• Published in: Drug testing and analysis Vol. 10; no. 3; p. 557
• Main Authors: Pan, Pei-Pei, Wang, Jun, Luo, Jun, Wang, Shuang-Hu, Zhou, Yun-Fang, Chen, Sai-Zhen, Du, Zhou
• Format: Journal Article
• Language: English
• Published: England 01.03.2018
• Subjects: Analgesics, Opioid - blood; Analgesics, Opioid - metabolism; Analgesics, Opioid - pharmacokinetics; Animals; Antioxidants - pharmacology; Chromatography, High Pressure Liquid; Male; Methadone - blood; Methadone - metabolism; Methadone - pharmacokinetics; Narcotics - blood; Narcotics - metabolism; Narcotics - pharmacokinetics; Rats, Sprague-Dawley; Silymarin - pharmacology; Tandem Mass Spectrometry; silibinin; pharmacokinetics; methadone

The aim of the present study was to investigate the pharmacokinetic effect of silibinin on methadone in rats. Twenty-four male Sprague-Dawley rats were randomly divided into 4 groups: control group, single dose of 100 mg/kg group, multiple doses of 100 mg/kg group, and multiple doses of 30 mg/kg gro...