Response‐adaptive treatment allocation for clinical studies with recurrent event and terminal event data

• Published in: Statistics in medicine Vol. 41; no. 2; pp. 258 - 275
• Main Author: Su, Pei‐Fang
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 30.01.2022
• Subjects: allocation rule; balanced design; Clinical trials; Design of experiments; doubly adaptive biased coin design; fisher information matrix; Humans; Medical statistics; Medical treatment; power; Random Allocation; Research Design; Research methodology; Sample Size; Statistical methods; Treatment Outcome; allocation rule; fisher information matrix; doubly adaptive biased coin design; power; balanced design
• ISSN: 0277-6715; 1097-0258; 1097-0258
• DOI: 10.1002/sim.9235

In long‐term clinical studies, recurrent event data are frequently collected to contrast the efficacy of two different treatments. However, the recurrent event process can be stopped by a terminal event, such as death. For analyzing recurrent event and terminal event data, joint frailty modeling has...